4.1.1.49: phosphoenolpyruvate carboxykinase (ATP) This is an abbreviated version! For detailed information about phosphoenolpyruvate carboxykinase (ATP), go to the full flat file .
Word Map on EC 4.1.1.49
Reaction
ATP +
oxaloacetate =
ADP +
phosphoenolpyruvate +
CO2
Synonyms ADP-linked PEP carboxykinase, ATP, oxaloacetate carboxy-lyase (transphosphorylating), ATP-dependent phosphoenolpyruvate carboxykinase, ATP-dependent phosphoenolpyruvate(PEP)carboxykinase, ATP-forming PEP-carboxykinase, ATP-oxaloacetate carboxylase (transphosphorylating), ATP: oxaloacetate carboxy-lyase, ATP:oxaloacetate carboxy-lyase, ATP:oxaloacetate carboxylyase (transphosphorylating), Carboxykinase, phosphopyruvate (adenosine triphosphate), Glycosomal protein P60, LMJF_27_1810, OsPPCK1, OsPPCK3, PCK, pckA, PEP carboxykinase, PEP carboxylase, PEP carboxylase kinase, PEPC, PEPC kinase, PEPCK, PEPCK (ATP), PEPCK-ATP, PEPK, PfPEPCK, phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase ATP-dependent, phosphoenolpyruvate carboxykinase [ATP], Phosphoenolpyruvate carboxylase, Phosphoenolpyruvate carboxylase (ATP), phosphoenolpyruvate carboxylase kinase, phosphoenolpyruvate(PEP)carboxykinase (GTP/ATP:oxaloacetate carboxy-lyase (transphosphorylating)EC 4.1.1.32/49), phosphoenolpyruvic carboxykinase, Phosphoenolpyruvic carboxylase, phosphopyruvate carboxykinase, Phosphopyruvate carboxykinase (adenosine triphosphate), PPC, PPCK, Protein p60, yeast PEP carboxykinase
ECTree
General Information
General Information on EC 4.1.1.49 - phosphoenolpyruvate carboxykinase (ATP)
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malfunction
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lack of phosphoenolpyruvate carboxykinase leads to activation of AMP-activated protein kinase, which inhibits cAMP-induced steroidogenic gene promoter activity and gene expression
malfunction
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Brucella suis 513 attenuation occurrs only in the double phosphoenolpyruvate carboxykinase (PckA) / pyruvate phosphate dikinase (PpdK) mutant
malfunction
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Brucella suis 513 attenuation occurrs only in the double phosphoenolpyruvate carboxykinase (PckA) / pyruvate phosphate dikinase (PpdK) mutant
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metabolism
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Brucella suis 513 used pyruvate phosphate dikinase (PpdK) and phosphoenolpyruvate carboxykinase (PckA) for phosphoenolpyruvate synthesis in vitro
metabolism
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Brucella suis 513 used pyruvate phosphate dikinase (PpdK) and phosphoenolpyruvate carboxykinase (PckA) for phosphoenolpyruvate synthesis in vitro
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physiological function
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the enzyme is required for steroidogenesis in testicular Leydig cells
physiological function
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both phosphoenolpyruvate carboxykinase and diphosphate-dependent pyruvate phosphate dikinase colocalize with glycolytic enzymes within the glycosomes of Trypanosoma evansi. Both enzymes can make use of PEP for contributing to the production of ATP within the organelles
physiological function
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Danio rerio larvae show increased V-ATPase-mediated acid secretion and transient expression of Pck1, in response to acid stress. Pck1 gene knockdown decreases the H+ secretion via V-ATPase, the effect is rescued by supplementation of glucose into the yolk. Pck1 knockdown does not affect glutamine/glutamate catalysis
physiological function
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Brucella suis biovar 5 depends on phosphoenolpyruvate carboxykinase and pyruvate phosphate dikinase for full virulence in laboratory models
physiological function
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Brucella suis biovar 5 depends on phosphoenolpyruvate carboxykinase and pyruvate phosphate dikinase for full virulence in laboratory models
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