3.7.1.2: fumarylacetoacetase

This is an abbreviated version!
For detailed information about fumarylacetoacetase, go to the full flat file.

Word Map on EC 3.7.1.2

3.7.1.2

tyrosinemia

hereditary

flavone

hepatocytes

anticipatory

aviation

succinylacetone

schedule

oscillator

rhythm

circadian

entrain

frontal

ntbc

flight

meal

asymmetry

clock

federal

aircraft

locomotor

fanconi

repopulation

food-entrainable

suprachiasmatic

civil

taurine

n-2-fluorenylacetamide

accident

certification

antitumour

medicine

homogentisate

4-hydroxyphenylpyruvate

mealtime

maleylacetoacetate

rickets

aerospace

dorsomedial

xaa

electroencephalography

hepatorenal

civilian

zeitgeber

4-aminoantipyrine

anteversion

dipyrone

light-entrainable

biotechnology

degradation

Reaction

Synonyms

4-fumarylacetoacetate fumarylhydrolase, acylpyruvase, AtFAH, beta-diketonase, diketo acid hydrolase, EaFAH, FAA, FAA hydrolase, FAH, fumarylacetoacetase, fumarylacetoacetate hydrolase, HmgB, mFAH, NagK, SSCD1, TTHA0809

ECTree

3 Hydrolases

3.7 Acting on carbon-carbon bonds

3.7.1 In ketonic substances

3.7.1.2 fumarylacetoacetase

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Results	in table
13789	AA Sequence
30	Application
1	CAS Registry Number
16	Cloned(Commentary)
5	Crystallization (Commentary)
1273	Disease/ Diagnostics
2	Expression
15	General Information
39	Inhibitors
3	Ki Value [mM]
15	KM Value [mM]
4	Localization
11	Metals/Ions
17	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
57	Organism
7	Pathway
18	PDB ID
11	pH Optimum
3	pH Range
1	pI Value
35	Protein Variants
20	Purification (Commentary)
3	Reaction
7	Reaction Type
57	Reference
43	Source Tissue
34	Specific Activity [micromol/min/mg]
4	Storage Stability
84	Substrates and Products (Substrate)
15	Subunits
75	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.7.1.2 - fumarylacetoacetase

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3-benzoylpropionate

Bos taurus

1 mM, 40% inhibition

289242

3-[(3-carboxy-2-oxopropyl)hydroxyphosphinyl]acrylate

2 entries

4-(hydroxymethylphosphinoyl)-3-oxo-butanoic acid

4-ethyl oxaloacetate

1 mM, 30% inhibition

4-ketopimelate

1 mM, 10% inhibition

4-[(2-carboxyethyl)-hydroxyphosphinyl]-3-oxobutyrate

2 entries

5,5'-dithiobis(2-nitrobenzoic acid)

acetoacetate

1 mM, 30% inhibition

alpha-Ketobutyrate

1 mM, 50% inhibition

alpha-ketoglutarate

1 mM, 50% inhibition

Benzoylacetone

9 mM

Br-

50 mM for 50% inhibition

citrate

9 mM

Cl-

140 mM for 50% inhibition

289242

ClO4-

Bos taurus

6 mM for 50% inhibition

DFP

1 mM

Dihydroxytartrate

1 mM, 100% inhibition

289242

F-

Bos taurus

1.2 mM for 50% inhibition

289242

Fe3+

Bos taurus

inactivation by precipitating the proteins

289239

HCO3-

Bos taurus

170 mM for 50% inhibition

289242

La3+

Bos taurus

inactivation by precipitating the proteins

malonate

9 mM

N-ethylmaleimide

1 mM

NO3-

12 mM for 50% inhibition

oxalate

9 mM

oxaloacetate

1 mM, 90% inhibition

p-hydroxymercuribenzoate

pyruvate

SCN-

4.2 mM for 50% inhibition

289242

succinylacetone

Arabidopsis thaliana

Q8RW90

treatment of wild-type seedlings with succinylacetone mimicks the sscd1 phenotypes: the treated wild-type seedlings exhibit wilted leaves and slow-growth symptoms under long-day, these symptoms are more severe under short-day. The sscd1 mutant is more sensitive to succinylacetone than the wild type under long-day

734967

trichloroacetate

Bos taurus

1.2 mM for 50% inhibition

289242

Trinitrobenzenesulfonic acid

Bos taurus

1 mM

289241

additional information

3 entries