Application | Comment | Organism |
---|---|---|
medicine | type I tyrosinemia is caused by mutations in the fumarylacetoacetate hydrolase gene, the results establish worms as a model for the study of type I tyrosinemia | Caenorhabditis elegans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | RNAi directed against the K10C2.4 gene, encoding fumarylacetoacetate hydrolase, produces a lethal phenotype | Caenorhabditis elegans |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
46000 | - |
predicted molecular weight, verified by SDS-PAGE and Western blot | Caenorhabditis elegans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-fumarylacetoacetate + H2O | Caenorhabditis elegans | - |
acetoacetate + fumarate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | Q94272 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-fumarylacetoacetate + H2O | - |
Caenorhabditis elegans | acetoacetate + fumarate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAH | - |
Caenorhabditis elegans |
fumarylacetoacetase | - |
Caenorhabditis elegans |
fumarylacetoacetate hydrolase | - |
Caenorhabditis elegans |