3.7.1.2: fumarylacetoacetase
This is an abbreviated version!
For detailed information about fumarylacetoacetase, go to the full flat file.
Word Map on EC 3.7.1.2
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3.7.1.2
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tyrosinemia
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hereditary
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flavone
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hepatocytes
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anticipatory
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aviation
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succinylacetone
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schedule
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oscillator
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rhythm
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circadian
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entrain
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frontal
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ntbc
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flight
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meal
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asymmetry
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clock
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federal
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aircraft
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locomotor
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fanconi
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repopulation
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food-entrainable
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suprachiasmatic
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civil
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taurine
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n-2-fluorenylacetamide
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accident
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certification
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antitumour
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medicine
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homogentisate
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4-hydroxyphenylpyruvate
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mealtime
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maleylacetoacetate
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rickets
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aerospace
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dorsomedial
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xaa
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electroencephalography
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hepatorenal
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civilian
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zeitgeber
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4-aminoantipyrine
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anteversion
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dipyrone
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light-entrainable
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biotechnology
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degradation
- 3.7.1.2
- tyrosinemia
- hereditary
- flavone
- hepatocytes
-
anticipatory
-
aviation
- succinylacetone
-
schedule
-
oscillator
-
rhythm
-
circadian
-
entrain
-
frontal
- ntbc
-
flight
- meal
-
asymmetry
- clock
-
federal
-
aircraft
-
locomotor
-
fanconi
-
repopulation
-
food-entrainable
-
suprachiasmatic
-
civil
- taurine
-
n-2-fluorenylacetamide
- accident
-
certification
-
antitumour
- medicine
- homogentisate
- 4-hydroxyphenylpyruvate
-
mealtime
- maleylacetoacetate
-
rickets
-
aerospace
-
dorsomedial
- xaa
-
electroencephalography
-
hepatorenal
-
civilian
-
zeitgeber
- 4-aminoantipyrine
-
anteversion
-
dipyrone
-
light-entrainable
- biotechnology
- degradation
Reaction
Synonyms
4-fumarylacetoacetate fumarylhydrolase, acylpyruvase, AtFAH, beta-diketonase, diketo acid hydrolase, EaFAH, FAA, FAA hydrolase, FAH, fumarylacetoacetase, fumarylacetoacetate hydrolase, HmgB, mFAH, NagK, SSCD1, TTHA0809
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Substrates Products
Substrates Products on EC 3.7.1.2 - fumarylacetoacetase
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REACTION DIAGRAM
2,4-diketo-4-(4-methylphenyl)butyrate + H2O
pyruvate + (4-methylphenyl)acetate
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?
2,4-diketo-5,5-dimethylhexanoate + H2O
pyruvate + 2,2-dimethylpropanoate
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-
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?
2,4-diketo-5-methylheptanoate + H2O
pyruvate + 2-methylbutanoate
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-
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?
acetoacetate + fumarate
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-
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?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
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-
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?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
final step in the Tyr degradation pathway
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-
?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
the enzyme catalyzes the last step in the Tyr degradation pathway
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?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
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?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
final step in the Tyr degradation pathway
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?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
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?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
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final step of Phe and Tyr degradation, essential metabolic function, loss of enzyme function causes the fatal metabolic disease hereditary tyrosinemia type I, i.e. HT1
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?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
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final step of Phe and Tyr degradation, essential metabolic function, loss of enzyme function causes the fatal metabolic disease hereditary tyrosinemia type I, i.e. HT1
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-
?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
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formation of a tetrahedral alkoxy transition state intermediate
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?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
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?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
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?
4-nitrophenol + acetate
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?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
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?
4-nitrophenol + butyrate
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?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
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?
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no activity with 4-nitrophenyl hexanoate, alpha-terpinyl acetate or 4-nitrophenyl phosphate
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additional information
?
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no activity with 4-nitrophenyl hexanoate, alpha-terpinyl acetate or 4-nitrophenyl phosphate
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additional information
?
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no activity with 4-nitrophenyl hexanoate, alpha-terpinyl acetate or 4-nitrophenyl phosphate
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