3.6.5.3: protein-synthesizing GTPase

This is an abbreviated version!
For detailed information about protein-synthesizing GTPase, go to the full flat file.

Reaction

Synonyms

50S ribosomal subunit assembly factor, aEF-1alpha, aIF2, aIF2 GTPase, aIF2-gamma, aIF2B, aIF2gamma, aIF5B, archaeal initiation factor 2, archaeal initiation factor 2C, archaeal translation initiation factor 2, BipA, BPI-inducible protein A, Bst-IF2, chloroplast elongation factor G, EC 3.6.1.48, Ec-L10, Ec-L11, Ec-L12, Eco-IF2, eEF1A, eEF2, EF 1 alpha, EF-1alpha, EF-1beta, EF-2, EF-4, EF-G, EF-G GTPase, EF-G1, EF-G1mt, EF-like GTPase, EF-Tu, EF-Tumt, EF4, EFL, Efl1, Efl1 GTPase, eIEF2, eIF 2, eIF2, eIF2A, eIF2alpha, eIF2B, eIF5, eIF5B, elongation factor, elongation factor (EF), elongation factor 1 alpha, elongation factor 1alpha, elongation factor 2, elongation factor 4, elongation factor G, elongation factor thermo unstable, elongation factor Tu, elongation factor-1alpha, elongation factor-1beta, elongation factor-2, elongation factor-like 1, elongation factor-like 1 GTPase, eukaryotic elongation factor 2, eukaryotic elongation factor one alpha, eukaryotic initiation factor 2, eukaryotic initiation factor 2A, eukaryotic initiation factor 5B, eukaryotic translation initiation factor 2, eukaryotic translation initiation factor 5B, fusA, GTP phosphohydrolase, GTPase, GTPase aIF5B, GTPase HflX, GTPase-activating protein, guanine triphosphatase, guanine-nucleotide-exchange factor of eIF2, guanosine 5'-triphosphatase, guanosine triphosphatase, HflX, HflX GTPase, IF-2, IF1, IF2, IF2 GTPase, IF2alpha, IF3, IF5B, infB, initiation factor (IF), initiation factor 2, initiation factor 3, initiation factor 5B, initiation factor aIF5B, initiation factor-2, L10, L11, L12, LepA, mitochondrial elongation factor G, mitochondrial initiation factor 2, peptide-release or termination factor, protein-synthesizing GTPase, protein-sythesizing GTPase, RF3, ribosomal GTPase, ribosome-bound initiation factor 2, ribosome-dependent GTPase, SelB, selenocysteine tRNA-specific elongation factor, signal recognition particle GTPase Ffh, SRP GTPase Ffh, Ss-aIF2, SsEF-1alpha, SsEF-2, SsGBP, SSO0269, SSO0412, SSO1050, SSO2381, SsoHflX, translation elongation factor 2, translation factor aIF2/5B, translation initiation factor, translation initiation factor 2, translation initiation factor 2 gamma, translation initiation factor 5B, translation initiation factor eIF5, translation initiation factor IF1, translation initiation factor IF2, translation termination factor eRF3, translational GTPase, translational guanosine triphosphatase, translational initiation factor 2, trGTPase, Tt-L11, ymIF2

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.5 Acting on GTP to facilitate cellular and subcellular movement

                3.6.5.3 protein-synthesizing GTPase

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Results	in table
61	Activating Compound
7969	AA Sequence
33	Application
1	CAS Registry Number
48	Cloned(Commentary)
1	Cofactor
34	Crystallization (Commentary)
5900	Disease/ Diagnostics
10	Expression
112	General Information
4	General Stability
5	IC50 Value
84	Inhibitors
14	kcat/KM [mM/s]
21	Ki Value [mM]
66	KM Value [mM]
25	Localization
54	Metals/Ions
29	Molecular Weight [Da]
130	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
976	Organism
16	PDB ID
23	pH Optimum
2	pI Value
18	Posttranslational Modification
138	Protein Variants
53	Purification (Commentary)
6	Reaction
24	Reaction Type
191	Reference
1	Renatured (Commentary)
18	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
221	Substrates and Products (Substrate)
32	Subunits
375	Synonyms
1	Systematic Name
40	Temperature Optimum [°C]
3	Temperature Range [°C]
16	Temperature Stability [°C]
48	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.6.5.3 - protein-synthesizing GTPase

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SYSTEMATIC NAME

IUBMB Comments

GTP phosphohydrolase (mRNA-translation-assisting)

This enzyme comprises a family of proteins involved in prokaryotic as well as eukaryotic protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyses it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolysing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1alpha (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF-1alpha catalyse binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyse the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs.