Information on EC 3.6.5.3 - protein-synthesizing GTPase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
3.6.5.3
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RECOMMENDED NAME
GeneOntology No.
protein-synthesizing GTPase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GTP + H2O = GDP + phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis
hydrolysis of phosphoric ester
additional information
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
NIL
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SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (mRNA-translation-assisting)
This enzyme comprises a family of proteins involved in prokaryotic as well as eukaryotic protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyses it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolysing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1alpha (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF-1alpha catalyse binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyse the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs.
CAS REGISTRY NUMBER
COMMENTARY hide
9059-32-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
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Acutodesmus obliquus
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1152110 A+, 1172635 A+, 1186986 A+, 1189654 A+, 1189686 A+, 1190037 A+, 1190129 A+, 1190221 A+, 1190223 A+, 1190246 A+, 1190247 A+, 1190281 A+, 1190333 A+, 1190359 A+, 1190377 A+, 1190408 A+, 1190426 A+, 1190528 A+, 1190566 A+, 1190706 A+, 1190708 A+, 1190739 A+, 1190795 A+, 1190861 A+, 1190893 A+, 1190924 A+, 1203283 A+, 1252385 A+, 1464406 A+, 1640452 A+, 1710474 A+, 1757010 A+, 1781448 A+, 2000585 A+, 2001507 A+, 2015302 A+, 2016141 A+, 2016375 A+, 2017213 A+, 2017638 A+, 2018342 A+, 2018376 A+, 2018387 A+, 2018395 A+, 2018437 A+, 2018509 A+, 2018560 A+, 2018566 A+, 2018673 A+, 2018700 A+, 2018733 A+, 2019083 A+, 2019145 A+, 2019165 A+, 2019258 A+, 2019396 A+, 2019406 A+, 2019649 A+, 2190007 A+, 2359166 A+, 2360471 A+, 2361536 A+, 2362312 A+, 2363184 A+, 2363355 A+, 2363372 A+, 2363467 A+, 2363483 A+, 2363498 A+, 2363504 A+, 2363571 A+, 2363614 A+, 2363661 A+, 2363667 A+, 2363690 A+, 2363691 A+, 2363717 A+, 2363743 A+, 2363760 A+, 2363761 A+, 2363765 A+, 2363835 A+, 2363839 A+, 2363864 A+, 2363894 A+, 2363911 A+, 2363919 A+, 2363933 A+, 2363940 A+, 2363967 A+, 2363975 A+, 2363979 A+, 2762330 A+, 2915211 A+, 2915276 A+, 2969766 A+, 2999986 A+, 3036874 A+, 3038805 A+, 3038890 A+, 3038966 A+, 3039632 A+, 3039746 A+, 3040591 A+, 3042006 A+, 3042063 A+, 3042094 A+, 3042096 A+, 3042213 A+, 3042303 A+, 3042325 A+, 3042407 A+, 3042497 A+, 3042549 A+, 3042633 A+, 3042639 A+, 3042650 A+, 3042704 A+, 667314 A+, 673633 A+, 735171 A+, 898957 A+, 955423 A+, 1190111 A+++, 1190527 A+++, 1190675 A+++
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gene lepA
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Manually annotated by BRENDA team
Escherichia coli DH5-alpha
strain DH5alpha
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Manually annotated by BRENDA team
strain HW110, EF-Tu (wt) and EF-Tu (138N)
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strain N4830, elongation factor EF-Tu (wt) and EF-Tu (D80N)
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
Pleodorina sp.
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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protozoa
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
strain 8830, elongation factor EF-Tu
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Manually annotated by BRENDA team
elongation factor (EF)Tu
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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1126791 A+, 1129887 A+, 1135355 A+, 1140738 A+, 1189697 A+, 1189704 A+, 1189753 A+, 1189756 A+, 1189761 A+, 1189765 A+, 1189807 A+, 1189815 A+, 1189823 A+, 1189957 A+, 1190159 A+, 1190188 A+, 1190207 A+, 1190208 A+, 1190210 A+, 1190216 A+, 1190224 A+, 1190241 A+, 1190265 A+, 1190267 A+, 1190291 A+, 1190309 A+, 1190323 A+, 1190360 A+, 1190429 A+, 1190437 A+, 1190446 A+, 1190449 A+, 1190454 A+, 1190516 A+, 1190546 A+, 1190616 A+, 1190821 A+, 1190837 A+, 1190856 A+, 1190878 A+, 1190896 A+, 1221823 A+, 1250015 A+, 1329569 A+, 1354421 A+, 1365142 A+, 1374289 A+, 1391135 A+, 1575407 A+, 1681227 A+, 1836747 A+, 1929103 A+, 2011145 A+, 2018339 A+, 2018364 A+, 2018394 A+, 2018404 A+, 2018406 A+, 2018428 A+, 2018439 A+, 2018443 A+, 2018459 A+, 2018460 A+, 2018466 A+, 2018473 A+, 2018489 A+, 2018500 A+, 2018528 A+, 2018548 A+, 2018609 A+, 2018695 A+, 2018737 A+, 2018776 A+, 2018812 A+, 2018929 A+, 2019119 A+, 2019606 A+, 2019647 A+, 2251378 A+, 2321863 A+, 2321881 A+, 2322811 A+, 2323199 A+, 2323340 A+, 2326155 A+, 2358275 A+, 2358426 A+, 2360733 A+, 2362051 A+, 2363316 A+, 2363390 A+, 2363417 A+, 2363419 A+, 2363466 A+, 2363491 A+, 2363513 A+, 2363514 A+, 2363524 A+, 2363538 A+, 2363554 A+, 2363564 A+, 2363581 A+, 2363591 A+, 2363606 A+, 2363623 A+, 2363770 A+, 2363914 A+, 2374130 A+, 2390418 A+, 2419119 A+, 2504932 A+, 2570686 A+, 2571599 A+, 2603095 A+, 2663149 A+, 2681747 A+, 2727698 A+, 2729626 A+, 2730471 A+, 2772421 A+, 2775675 A+, 2925823 A+, 2950353 A+, 2961091 A+, 2966640 A+, 2968702 A+, 2969438 A+, 3041881 A+, 3041887 A+, 3041895 A+, 3041896 A+, 3041931 A+, 3041933 A+, 3041962 A+, 3041981 A+, 3042003 A+, 3042088 A+, 3042110 A+, 3042133 A+, 3042212 A+, 3042215 A+, 3042708 A+, 644134 A+, 915413 A+, 955895 A+, 969851 A+, 1129256 A+++, 1189735 A+++, 1189775 A+++, 1189977 A+++, 1189979 A+++, 1189980 A+++, 1189995 A+++, 1189997 A+++, 1189998 A+++, 1190245 A+++, 1190263 A+++, 1190269 A+++, 1190315 A+++, 1190488 A+++, 1190694 A+++, 1190740 A+++, 1190798 A+++, 1190882 A+++, 980165 A+++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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