3.5.3.15: protein-arginine deiminase

This is an abbreviated version!
For detailed information about protein-arginine deiminase, go to the full flat file.

Reaction

Synonyms

deiminase, protein (arginine), HL-60 PAD, hPADI2, hPADI4, hPADVI, PAD, PAD 1, PAD 2, PAD 3, PAD 4, PAD II, PAD IV, PAD type 2, PAD-4, PAD-H19, PAD-R11, PAD-R4, PAD1, PAD2, PAD3, PAD4, PAD6, PADI1, Padi2, PADI3, PADI4, peptidyl arginine deiminas 4, peptidyl arginine deiminase, peptidyl arginine deiminase 2, peptidyl-arginine deiminase, peptidylarginine deiminase, peptidylarginine deiminase 1, peptidylarginine deiminase 2, peptidylarginine deiminase 3, peptidylarginine deiminase 4, peptidylarginine deiminase 6, peptidylarginine deiminase isoform VI, peptidylarginine deiminase IV, peptidylarginine deiminase type 4, Peptidylarginine deiminase type alpha, peptidylarginine deiminase type I, peptidylarginine deiminase type II, peptidylarginine deiminase type III, peptidylarginine deiminase type VI, peptidylarginine deiminase-4, PPAD, protein arginine deiminase, protein arginine deiminase 2, protein arginine deiminase 3, protein arginine deiminase 4

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.3 In linear amidines

                3.5.3.15 protein-arginine deiminase

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Results	in table
12	Activating Compound
2099	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
12	Crystallization (Commentary)
1778	Disease/ Diagnostics
9	Expression
20	General Information
2	General Stability
35	IC50 Value
123	Inhibitors
178	kcat/KM [mM/s]
7	Ki Value [mM]
237	KM Value [mM]
40	Localization
53	Metals/Ions
24	Molecular Weight [Da]
72	Natural Substrates/ Products (Substrates)
199	Organism
1	Pathway
62	PDB ID
26	pH Optimum
7	pH Range
2	pI Value
5	Posttranslational Modification
136	Protein Variants
23	Purification (Commentary)
1	Reaction
1	Reaction Type
152	Reference
257	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
510	Substrates and Products (Substrate)
20	Subunits
224	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
203	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.5.3.15 - protein-arginine deiminase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0028 - 0.026

1-[[4-(benzoylamino)-5-(ethylamino)-5-oxopentyl]amino]-2-chloroethaniminium

3 entries

0.0243 - 0.157

1-[[4-(benzoylamino)-5-(ethylamino)-5-oxopentyl]amino]-2-fluoroethaniminium

3 entries

0.5

2-chloroacetamidine

Homo sapiens

-

IC50 above 0.5 mM, in 100 mM Tris-HCl (pH 7.6), CaCl2 (10 mM), dithiothreitol (5 mM), at 37°C

711811

10

5-aminosalicylic acid

Homo sapiens

-

above, pH 7.6, 37°C, recombinant PAD4

685554

8.1

Azathioprine

Homo sapiens

-

pH 7.6, 37°C, recombinant PAD4

685554

10

azithromycin

Homo sapiens

-

above, pH 7.6, 37°C, recombinant PAD4

685554

0.4

benzoyl-Ngamma,Ngamma-dimethyl-Arg

Homo sapiens

Q9UM07

IC50: 0.4 mM

664957

0.1

chlortetracycline

Homo sapiens

-

in 100 mM Tris-HCl (pH 7.6), CaCl2 (10 mM), dithiothreitol (2 mM) and NaCl (50 mM) at 37°C

711811

0.0008 - 0.022

Cl-amidine

3 entries

5.1

clindamycin

Homo sapiens

-

pH 7.6, 37°C, recombinant PAD4

685554

0.0216 - 0.35

F-amidine

4 entries

0.13

H2O2

Homo sapiens

Q9UM07, Q9Y2J8

pH 7.4, 23°C

754285

2.4

leflunomide

Homo sapiens

-

pH 7.6, 37°C, recombinant PAD4

685554

10

methotrexate

Homo sapiens

-

above, pH 7.6, 37°C, recombinant PAD4

685554

0.5

N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine ethyl ester

Homo sapiens

Q9Y2J8

recombinant PAD4, pH 7.6, 37°C

684402

0.0058

N-[([1,1'-biphenyl]-3-yl)methyl]-4-[(2-chloroethanimidoyl)amino]butanamide

Homo sapiens

Q9ULW8

pH not specified in the publication, temperature not specified in the publication

752368

0.0054

N-[3-[5-([1,1'-biphenyl]-3-yl)-1H-imidazol-2-yl]propyl](chloro)ethanimidamide

Homo sapiens

Q9ULW8

pH not specified in the publication, temperature not specified in the publication

752368

0.0074

N-{(2S)-1-amino-5-[(2-chloroethanimidoyl)amino]-1-oxopentan-2-yl}benzamide

Homo sapiens

-

in 100 mM HEPES (pH 7.6), CaCl2 (10 mM), TCEP (0.5 mM), NaCl (50 mM), temperature not specified in the publication

711811

0.024

N-{(2S)-1-amino-5-[(2-fluoroethanimidoyl)amino]-1-oxopentan-2-yl}benzamide

Homo sapiens

-

in 100 mM HEPES (pH 7.6), CaCl2 (10 mM), TCEP (0.5 mM), NaCl (50 mM), temperature not specified in the publication

711811

0.4

N2-benzoyl-N5-(N,N-dimethylcarbamimidoyl)-L-ornithine

Homo sapiens

-

in 100 mM Tris-HCl (pH 7.6), CaCl2 (10 mM), dithiothreitol (1 mM), at 37°C

711811

5

paclitaxel

Homo sapiens

-

IC50 is about 5 mM, at 52°C for 30 min in 50 mM HEPES (pH 7.6), CaCl2 (5 mM), dithiothreitol (2 mM)

711811

1.8

streptomycin

Homo sapiens

-

pH 7.6, 37°C, recombinant PAD4

685554

10

sulfamethoxazole

Homo sapiens

-

above, pH 7.6, 37°C, recombinant PAD4

685554

10

sulfapyridine

Homo sapiens

-

above, pH 7.6, 37°C, recombinant PAD4

685554

0.78

tetracycline

Homo sapiens

-

in 100 mM Tris-HCl (pH 7.6), CaCl2 (10 mM), dithiothreitol (2 mM) and NaCl (50 mM) at 37°C

711811

7.5

trimethoprim

Homo sapiens

-

pH 7.6, 37°C, recombinant PAD4

685554

0.0028

1-[[4-(benzoylamino)-5-(ethylamino)-5-oxopentyl]amino]-2-chloroethaniminium

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.0041

1-[[4-(benzoylamino)-5-(ethylamino)-5-oxopentyl]amino]-2-chloroethaniminium

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.026

1-[[4-(benzoylamino)-5-(ethylamino)-5-oxopentyl]amino]-2-chloroethaniminium

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.0243

1-[[4-(benzoylamino)-5-(ethylamino)-5-oxopentyl]amino]-2-fluoroethaniminium

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.04

1-[[4-(benzoylamino)-5-(ethylamino)-5-oxopentyl]amino]-2-fluoroethaniminium

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.157

1-[[4-(benzoylamino)-5-(ethylamino)-5-oxopentyl]amino]-2-fluoroethaniminium

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.0008

Cl-amidine

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.0062

Cl-amidine

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.022

Cl-amidine

Homo sapiens

-

in 100 mM HEPES (pH 7.6), CaCl2 (10 mM), TCEP (0.5 mM), NaCl (50 mM), temperature not specified in the publication

711811

0.0216

F-amidine

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.022

F-amidine

Homo sapiens

-

in 100 mM HEPES (pH 7.6), CaCl2 (10 mM), TCEP (0.5 mM), NaCl (50 mM), temperature not specified in the publication

711811

0.0295

F-amidine

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.35

F-amidine

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246