3.5.3.15: protein-arginine deiminase

This is an abbreviated version!
For detailed information about protein-arginine deiminase, go to the full flat file.

Reaction

Synonyms

deiminase, protein (arginine), HL-60 PAD, hPADI2, hPADI4, hPADVI, PAD, PAD 1, PAD 2, PAD 3, PAD 4, PAD II, PAD IV, PAD type 2, PAD-4, PAD-H19, PAD-R11, PAD-R4, PAD1, PAD2, PAD3, PAD4, PAD6, PADI1, Padi2, PADI3, PADI4, peptidyl arginine deiminas 4, peptidyl arginine deiminase, peptidyl arginine deiminase 2, peptidyl-arginine deiminase, peptidylarginine deiminase, peptidylarginine deiminase 1, peptidylarginine deiminase 2, peptidylarginine deiminase 3, peptidylarginine deiminase 4, peptidylarginine deiminase 6, peptidylarginine deiminase isoform VI, peptidylarginine deiminase IV, peptidylarginine deiminase type 4, Peptidylarginine deiminase type alpha, peptidylarginine deiminase type I, peptidylarginine deiminase type II, peptidylarginine deiminase type III, peptidylarginine deiminase type VI, peptidylarginine deiminase-4, PPAD, protein arginine deiminase, protein arginine deiminase 2, protein arginine deiminase 3, protein arginine deiminase 4

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.3 In linear amidines

                3.5.3.15 protein-arginine deiminase

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Results	in table
12	Activating Compound
2099	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
12	Crystallization (Commentary)
1778	Disease/ Diagnostics
9	Expression
20	General Information
2	General Stability
35	IC50 Value
123	Inhibitors
178	kcat/KM [mM/s]
7	Ki Value [mM]
237	KM Value [mM]
40	Localization
53	Metals/Ions
24	Molecular Weight [Da]
72	Natural Substrates/ Products (Substrates)
199	Organism
1	Pathway
62	PDB ID
26	pH Optimum
7	pH Range
2	pI Value
5	Posttranslational Modification
136	Protein Variants
23	Purification (Commentary)
1	Reaction
1	Reaction Type
152	Reference
257	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
510	Substrates and Products (Substrate)
20	Subunits
224	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
203	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 3.5.3.15 - protein-arginine deiminase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.2 - 5.7

2-acetyl-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

3 entries

0.001 - 1.4

3-acetyl-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

3 entries

0.22 - 3.5

Ac-Ala-Gly-Arg-Gly-Lys

3 entries

0.9 - 5.8

Ac-Ser-Ala-Arg-Gly-Lys

3 entries

0.01 - 3.3

Ac-Ser-Gly-Ala-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val

3 entries

0.08 - 6.6

Ac-Ser-Gly-Arg-Ala-Lys

3 entries

1.8 - 3.9

Ac-Ser-Gly-Arg-Gly-acetyl-Lys-Gly-Gly-acetyl-Lys-Gly-Leu-Gly-acetyl-Lys-Gly-Gly-Ala-acetyl-Lys

3 entries

0.05 - 16

Ac-Ser-Gly-Arg-Gly-Ala

3 entries

0.001 - 3.3

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly

3 entries

2 - 4.6

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala

3 entries

1 - 19

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Ala-Val

3 entries

0.7 - 14

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val

3 entries

0.5 - 3.9

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

3 entries

0.3 - 2.7

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Ala-His-Arg-Ala-Val

3 entries

2.5 - 4.4

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His

3 entries

0.001 - 3.7

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Ala-Ala-Val

3 entries

0.7 - 5.3

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val

3 entries

0.4 - 1.2

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Lys-His-Lys-Ala-Val

3 entries

0.7 - 9

histone H4-L-arginine

3 entries

0.184 - 0.391

IHAREIFDSR

2 entries

0.13 - 120000

N-alpha-benzoyl-L-arginine amide

4 entries

0.005 - 13800

N-alpha-benzoyl-L-arginine ethyl ester

64 entries

0.12 - 10.4

N-alpha-benzoyl-L-arginine methyl ester

3 entries

0.63 - 6.4

Nalpha-benzoyl L-arginine ethyl ester

20 entries

0.39

Nalpha-benzoyl-L-arginine

Homo sapiens

Q9Y2J8

at pH 7.6 and 37°C

733351

0.68

Nalpha-benzoyl-L-arginine amide

Homo sapiens

Q9Y2J8

at pH 7.6 and 37°C

733351

11.7

Nalpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

at pH 7.6 and 37°C

733351

1.8

Nalpha-benzoyl-L-arginine methyl ester

Homo sapiens

Q9Y2J8

at pH 7.6 and 37°C

733351

0.255 - 0.563

PPGFSPFR

2 entries

0.0031 - 10

[histone H4]-L-Arg

22 entries

0.2

2-acetyl-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

4.2

2-acetyl-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

5.7

2-acetyl-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.001

3-acetyl-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

Homo sapiens

-

kcat_Km value less than 0.001 mM-1*sec-1, isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

1.4

3-acetyl-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

1.4

3-acetyl-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.22

Ac-Ala-Gly-Arg-Gly-Lys

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

2

Ac-Ala-Gly-Arg-Gly-Lys

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3.5

Ac-Ala-Gly-Arg-Gly-Lys

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.9

Ac-Ser-Ala-Arg-Gly-Lys

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

1.4

Ac-Ser-Ala-Arg-Gly-Lys

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

5.8

Ac-Ser-Ala-Arg-Gly-Lys

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.01

Ac-Ser-Gly-Ala-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.58

Ac-Ser-Gly-Ala-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3.3

Ac-Ser-Gly-Ala-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.08

Ac-Ser-Gly-Arg-Ala-Lys

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

1.7

Ac-Ser-Gly-Arg-Ala-Lys

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

6.6

Ac-Ser-Gly-Arg-Ala-Lys

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

1.8

Ac-Ser-Gly-Arg-Gly-acetyl-Lys-Gly-Gly-acetyl-Lys-Gly-Leu-Gly-acetyl-Lys-Gly-Gly-Ala-acetyl-Lys

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3.4

Ac-Ser-Gly-Arg-Gly-acetyl-Lys-Gly-Gly-acetyl-Lys-Gly-Leu-Gly-acetyl-Lys-Gly-Gly-Ala-acetyl-Lys

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3.9

Ac-Ser-Gly-Arg-Gly-acetyl-Lys-Gly-Gly-acetyl-Lys-Gly-Leu-Gly-acetyl-Lys-Gly-Gly-Ala-acetyl-Lys

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.05

Ac-Ser-Gly-Arg-Gly-Ala

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

2.5

Ac-Ser-Gly-Arg-Gly-Ala

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

16

Ac-Ser-Gly-Arg-Gly-Ala

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.001

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly

Homo sapiens

-

kcat_Km value less than 0.001 mM-1*sec-1, isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.085

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3.3

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

2

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

4.4

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

4.6

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

1

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Ala-Val

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

2.3

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Ala-Val

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

19

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Ala-Val

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.7

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

1.3

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

14

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.5

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3.1

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3.9

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.3

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Ala-His-Arg-Ala-Val

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.6

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Ala-His-Arg-Ala-Val

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

2.7

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Ala-His-Arg-Ala-Val

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

2.5

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

4.4

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.001

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Ala-Ala-Val

Homo sapiens

-

kcat_Km value less than 0.001 mM-1*sec-1, isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.4

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Ala-Ala-Val

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3.7

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Ala-Ala-Val

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.7

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

4

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

5.3

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.4

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Lys-His-Lys-Ala-Val

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.5

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Lys-His-Lys-Ala-Val

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

1.2

Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Lys-His-Lys-Ala-Val

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.7

histone H4-L-arginine

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

4.3

histone H4-L-arginine

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

9

histone H4-L-arginine

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.184

IHAREIFDSR

Porphyromonas gingivalis

Q9RQJ2

pH 7.5, 37°C

755342

0.391

IHAREIFDSR

Porphyromonas gingivalis

Q9RQJ2

pH 7.5, 37°C

755342

0.13

N-alpha-benzoyl-L-arginine amide

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

11

N-alpha-benzoyl-L-arginine amide

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

22

N-alpha-benzoyl-L-arginine amide

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

120000

N-alpha-benzoyl-L-arginine amide

Homo sapiens

-

mutant PAD3 enzyme G374R, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.005

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme Q350A

752353

0.007

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant E412A, pH 7.6, 37°C

752353

0.007

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant R373A, pH 7.6, 37°C

752353

0.007

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme E412A

752353

0.007

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme W373A

752353

0.02

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant R372A, pH 7.5, 25°C

755469

0.025

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.05

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant Q350A, pH 7.6, 37°C

752353

0.05

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant R372Q, pH 7.5, 25°C

755469

0.075

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant E352A, pH 7.6, 37°C

752353

0.075

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme E352A

752353

0.1

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant V469L, pH 7.5, 25°C

755469

0.115

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant D370A, pH 7.6, 37°C

752353

0.115

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme D370A

752353

0.15

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant V469A, pH 7.5, 25°C

755469

0.195

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant D374A, pH 7.6, 37°C

752353

0.195

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme D374A

752353

0.35

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant R347A, pH 7.6, 37°C

752353

0.35

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme R347

752353

0.4

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant V469T, pH 7.5, 25°C

755469

0.845

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant D389A, pH 7.6, 37°C

752353

0.845

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme D389A

752353

0.9

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant Y435A, pH 7.5, 25°C

755469

1.065

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant D166A, pH 7.6, 37°C

752353

1.065

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme D166A

752353

1.1

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant D177A, pH 7.6, 37°C

752353

1.1

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme D177A

752353

1.4

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant R441A, pH 7.5, 25°C

755469

1.5

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

1.9

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant L279D, pH 7.5, 25°C

755469

2

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant W548K, pH 7.5, 25°C

755469

3.2

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant V284D, pH 7.5, 25°C

755469

3.7

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant V284A, pH 7.5, 25°C

755469

4.4

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

4.6

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant W548F, pH 7.5, 25°C

755469

6

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant D125A, pH 7.6, 37°C

752353

6

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme D125A

752353

6.3

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant V283T, pH 7.5, 25°C

755469

6.8

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant D123N, pH 7.6, 37°C

752353

6.8

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme D123N

752353

7.1

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant R639A, pH 7.5, 25°C

755469

7.9

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant D169A, pH 7.6, 37°C

752353

7.9

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme D169A

752353

8.6

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant F285A, pH 7.5, 25°C

755469

8.8

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant D465A, pH 7.5, 25°C

755469

9

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant L6D, pH 7.5, 25°C

755469

9.3

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant R374Q, pH 7.5, 25°C

755469

11

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant F541A, pH 7.5, 25°C

755469

11.1

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant R374A, pH 7.5, 25°C

755469

11.4

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant V283A, pH 7.5, 25°C

755469

12.2

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant L6A, pH 7.5, 25°C

755469

13.8

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant L279A, pH 7.5, 25°C

755469

16.5

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, wild-type enzyme

752353

16.5

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

wild-type, pH 7.6, 37°C

752353

18

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

mutant F221A/F222A, pH 7.6, 37°C

752353

18

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9Y2J8

pH 7.6, 37°C, mutant enzyme F221A/F222A

752353

19

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant V283I, pH 7.5, 25°C

755469

20

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant C434A, pH 7.5, 25°C

755469

21.8

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant L6I, pH 7.5, 25°C

755469

21.8

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant V284I, pH 7.5, 25°C

755469

23.4

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

wild-type, pH 7.5, 25°C

755469

24.5

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant F576A, pH 7.5, 25°C

755469

28

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

Q9UM07

mutant L279I, pH 7.5, 25°C

755469

13800

N-alpha-benzoyl-L-arginine ethyl ester

Homo sapiens

-

mutant PAD3 enzyme G374R, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.12

N-alpha-benzoyl-L-arginine methyl ester

Homo sapiens

-

isozyme PAD3, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3.3

N-alpha-benzoyl-L-arginine methyl ester

Homo sapiens

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

10.4

N-alpha-benzoyl-L-arginine methyl ester

Homo sapiens

-

isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

0.63

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R419Q

718900

1.3

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R639Q

718900

1.5

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R156K

718900

1.6

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R123Q

718900

1.7

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R609K

718900

1.8

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R374K

718900

1.9

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant A112G

718900

1.9

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R374Q

718900

2.1

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant A82V

718900

2.1

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R609Q

718900

2.2

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R156Q

718900

2.4

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R484K

718900

2.5

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R205K

718900

2.5

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R205Q

718900

2.7

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R484Q

718900

2.8

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R639K

718900

4.3

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R123K

718900

4.3

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant R419K

718900

4.8

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, wild-type

718900

6.4

Nalpha-benzoyl L-arginine ethyl ester

Homo sapiens

-

37°C, pH 7.6, mutant S55G

718900

0.255

PPGFSPFR

Porphyromonas gingivalis

Q9RQJ2

pH 7.5, 37°C

755342

0.563

PPGFSPFR

Porphyromonas gingivalis

Q9RQJ2

pH 7.5, 37°C

755342

0.0031

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R372K, value below

718900

0.012

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R372Q, value below

718900

2.1

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R205Q

718900

3.7

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R205K

718900

4

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant A82V

718900

4.9

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R609K

718900

5.1

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R374Q

718900

5.3

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R484Q

718900

5.5

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R419Q

718900

5.5

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant S55G

718900

5.6

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R374K

718900

5.9

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant A112G

718900

6.2

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R484K

718900

7.1

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R123K

718900

7.2

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R156Q

718900

7.8

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R156K

718900

8.3

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R609Q

718900

8.3

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R639Q

718900

8.7

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R639K

718900

9

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R123Q

718900

9.3

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, mutant R419K

718900

10

[histone H4]-L-Arg

Homo sapiens

-

37°C, pH 7.6, wild-type

718900