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3.5.3.15: protein-arginine deiminase

This is an abbreviated version!
For detailed information about protein-arginine deiminase, go to the full flat file.

Word Map on EC 3.5.3.15

Reaction

protein L-arginine
+
H2O
=
protein L-citrulline
 +
NH3

Synonyms

deiminase, protein (arginine), HL-60 PAD, hPADI2, hPADI4, hPADVI, PAD, PAD 1, PAD 2, PAD 3, PAD 4, PAD II, PAD IV, PAD type 2, PAD-4, PAD-H19, PAD-R11, PAD-R4, PAD1, PAD2, PAD3, PAD4, PAD6, PADI1, Padi2, PADI3, PADI4, peptidyl arginine deiminas 4, peptidyl arginine deiminase, peptidyl arginine deiminase 2, peptidyl-arginine deiminase, peptidylarginine deiminase, peptidylarginine deiminase 1, peptidylarginine deiminase 2, peptidylarginine deiminase 3, peptidylarginine deiminase 4, peptidylarginine deiminase 6, peptidylarginine deiminase isoform VI, peptidylarginine deiminase IV, peptidylarginine deiminase type 4, Peptidylarginine deiminase type alpha, peptidylarginine deiminase type I, peptidylarginine deiminase type II, peptidylarginine deiminase type III, peptidylarginine deiminase type VI, peptidylarginine deiminase-4, PPAD, protein arginine deiminase, protein arginine deiminase 2, protein arginine deiminase 3, protein arginine deiminase 4

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.3 In linear amidines
                3.5.3.15 protein-arginine deiminase

KM Value

KM Value on EC 3.5.3.15 - protein-arginine deiminase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.11 - 0.18
2-acetyl-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys
0.32 - 0.36
3-acetyl-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys
0.3 - 0.95
Ac-Ala-Gly-Arg-Gly-Lys
0.69 - 0.8
Ac-Ser-Ala-Arg-Gly-Lys
0.44 - 1.75
Ac-Ser-Gly-Ala-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val
0.58
Ac-Ser-Gly-Arg-Ala-Lys
-
isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol
0.15 - 1.07
Ac-Ser-Gly-Arg-Gly-acetyl-Lys-Gly-Gly-acetyl-Lys-Gly-Leu-Gly-acetyl-Lys-Gly-Gly-Ala-acetyl-Lys
0.37
Ac-Ser-Gly-Arg-Gly-Ala
-
isozyme PAD1, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol
0.86
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly
-
isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol
0.16 - 0.58
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala
0.17 - 0.34
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Ala-Val
0.43 - 0.66
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val
0.15 - 0.59
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys
1.7
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Ala-His-Arg-Ala-Val
-
isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol
0.22 - 1.95
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His
0.48 - 2.16
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Ala-Ala-Val
0.21 - 0.64
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val
0.48 - 3.27
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Lys-His-Lys-Ala-Val
0.91 - 11.3
acetyl-L-Arg
1.19 - 66.3
acetyl-L-Arg methyl ester
0.33 - 0.78
benzoyl-Arg ethyl ester
0.15 - 0.91
benzoyl-Arg-ethyl ester
0.63 - 1.97
benzoyl-Arg-methyl ester
0.16 - 1.23
benzoyl-Arg-NH2
0.028
benzoyl-Gly-L-Arg
-
-
0.0029 - 33.6
benzoyl-L-Arg
0.35 - 7.5
benzoyl-L-Arg ethyl ester
0.53 - 0.54
benzoyl-L-Arg methyl ester
0.152 - 1.39
benzoyl-L-Arg-NH2
0.41
benzoyl-L-arginine
37°C
0.25
benzoyl-L-arginine amide
37°C
1.36
benzoyl-L-arginine ethyl ester
37°C
1.66
benzoyl-L-arginine methyl ester
37°C
11.2
benzoylarginine ethyl ester
-
Km-value of the low activity binding site
0.047
bradykinin
-
-
0.013 - 0.055
fibrinogen
-
0.001 - 0.064
filaggrin
-
0.14
histone H4-L-arginine
-
isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol
0.0074 - 0.038
IHAREIFDSR
0.325
KDRNW
-
in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C
0.141 - 36.3
L-Arg
23.49 - 26.45
L-Arg methyl ester
0.45
LDRGE
-
in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C
0.27
MWRHV
-
in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C
0.16 - 17.5
N-alpha-benzoyl-L-arginine amide
0.1 - 30
N-alpha-benzoyl-L-arginine ethyl ester
0.37 - 10.8
N-alpha-benzoyl-L-arginine methyl ester
0.44 - 1.7
Nalpha-benzoyl L-arginine ethyl ester
0.41 - 1.6
Nalpha-benzoyl-L-arginine
0.25 - 0.48
Nalpha-benzoyl-L-arginine amide
0.27 - 2.77
Nalpha-benzoyl-L-arginine ethyl ester
0.24 - 1.66
Nalpha-benzoyl-L-arginine methyl ester
0.0054 - 0.045
PPGFSPFR
0.372
TKQTARKSTGGK
-
in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C
1.63 - 5.61
tosyl-Arg-ethyl ester
0.575
TSTGGRQGSHH
-
in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C
0.12
WSRYH
-
in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C
0.345
WTRGE
-
in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C
0.187
YWRDH
-
in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C
0.088 - 0.35
[histone H4]-L-Arg