3.5.3.15: protein-arginine deiminase

This is an abbreviated version!
For detailed information about protein-arginine deiminase, go to the full flat file.

Reaction

Synonyms

deiminase, protein (arginine), HL-60 PAD, hPADI2, hPADI4, hPADVI, PAD, PAD 1, PAD 2, PAD 3, PAD 4, PAD II, PAD IV, PAD type 2, PAD-4, PAD-H19, PAD-R11, PAD-R4, PAD1, PAD2, PAD3, PAD4, PAD6, PADI1, Padi2, PADI3, PADI4, peptidyl arginine deiminas 4, peptidyl arginine deiminase, peptidyl arginine deiminase 2, peptidyl-arginine deiminase, peptidylarginine deiminase, peptidylarginine deiminase 1, peptidylarginine deiminase 2, peptidylarginine deiminase 3, peptidylarginine deiminase 4, peptidylarginine deiminase 6, peptidylarginine deiminase isoform VI, peptidylarginine deiminase IV, peptidylarginine deiminase type 4, Peptidylarginine deiminase type alpha, peptidylarginine deiminase type I, peptidylarginine deiminase type II, peptidylarginine deiminase type III, peptidylarginine deiminase type VI, peptidylarginine deiminase-4, PPAD, protein arginine deiminase, protein arginine deiminase 2, protein arginine deiminase 3, protein arginine deiminase 4

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.3 In linear amidines

                3.5.3.15 protein-arginine deiminase

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Results	in table
12	Activating Compound
2099	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
12	Crystallization (Commentary)
1778	Disease/ Diagnostics
9	Expression
20	General Information
2	General Stability
35	IC50 Value
123	Inhibitors
178	kcat/KM [mM/s]
7	Ki Value [mM]
237	KM Value [mM]
40	Localization
53	Metals/Ions
24	Molecular Weight [Da]
72	Natural Substrates/ Products (Substrates)
199	Organism
1	Pathway
62	PDB ID
26	pH Optimum
7	pH Range
2	pI Value
5	Posttranslational Modification
136	Protein Variants
23	Purification (Commentary)
1	Reaction
1	Reaction Type
152	Reference
257	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
510	Substrates and Products (Substrate)
20	Subunits
224	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
203	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 3.5.3.15 - protein-arginine deiminase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

no modification

Mus musculus

-

the potential Asn-linked glycosylation site, Asn542-Glu543-Ser544 has no carbohydrate moiety

209419

proteolytic modification

Homo sapiens

-

PAD4 autodeimination does not alter the activity, substrate specificity, or calcium dependence of this isozyme. Six in vitro sites of autodeimination are identified: R123, R156, R205, R419, R484, and R639. Autodeimination of PAD4 reduces protein-protein interactions

718900

side-chain modification

2 entries

sumoylation

Giardia intestinalis

-

ADI is also sumoylated, which may modulate its activity

699105

side-chain modification

Bos taurus

-

methylation of Arg106 is a naturally occuring modification of the enzyme that affects deimination of Arg residues

209418

side-chain modification

Homo sapiens

-

methylation of Arg107 is a naturally occuring modification of the enzyme that affects deimination of Arg residues

209418