3.5.3.12: agmatine deiminase

This is an abbreviated version!
For detailed information about agmatine deiminase, go to the full flat file.

Reaction

Synonyms

AgD, AgDI, agmatine amidinohydrolase, agmatine deiminase, agmatine deiminaseHpAgD, agmatine iminohydrolase, agu2A, AguA, aguA protein, AguA1, aguA2, AIH, More, PgAgD, putrescine synthase, SmAgD

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.3 In linear amidines

                3.5.3.12 agmatine deiminase

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Results	in table
20	Activating Compound
6166	AA Sequence
16	Application
1	CAS Registry Number
11	Cloned(Commentary)
3	Crystallization (Commentary)
11	Expression
15	General Information
2	General Stability
17	IC50 Value
131	Inhibitors
20	kcat/KM [mM/s]
5	Ki Value [mM]
17	KM Value [mM]
6	Localization
33	Molecular Weight [Da]
53	Natural Substrates/ Products (Substrates)
164	Organism
6	Pathway
31	PDB ID
42	pH Optimum
9	pH Range
2	pH Stability
2	Posttranslational Modification
25	Protein Variants
24	Purification (Commentary)
6	Reaction
6	Reaction Type
103	Reference
33	Source Tissue
35	Specific Activity [micromol/min/mg]
8	Storage Stability
123	Substrates and Products (Substrate)
22	Subunits
85	Synonyms
1	Systematic Name
24	Temperature Optimum [°C]
2	Temperature Range [°C]
7	Temperature Stability [°C]
6	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.5.3.12 - agmatine deiminase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

221

2-chloroacetamidine

Listeria monocytogenes serotype 1/2a

A0A0H3G8U9

pH 7.5, 25°C

752712

0.013 - 2.89

Co2+

2 entries

0.034

Cu2+

Listeria monocytogenes

-

at 25°C and pH 7.5

734228

0.00087 - 0.0785

N-(4-aminobutyl)-2-chloro-ethanimidamide

2 entries

0.00026 - 0.015

N-(4-aminobutyl)-2-chloroethanimidamide

3 entries

0.0068 - 0.146

N-(4-aminobutyl)-2-fluoro-ethanimidamide

2 entries

0.00027 - 0.091

N-(4-aminobutyl)-2-fluoroethanimidamide

3 entries

0.1

Ni2+

Helicobacter pylori

Q9ZN18

wild-type, pH 8.0, 37°C

711375

0.03 - 0.25

Zn2+

2 entries

0.013

Co2+

Helicobacter pylori

Q9ZN18

wild-type, pH 8.0, 37°C

711375

2.89

Co2+

Listeria monocytogenes

-

at 25°C and pH 7.5

734228

0.00087

N-(4-aminobutyl)-2-chloro-ethanimidamide

Helicobacter pylori

Q9ZN18

wild-type, pH 8.0, 37°C

711375

0.0785

N-(4-aminobutyl)-2-chloro-ethanimidamide

Listeria monocytogenes serotype 1/2a

A0A0H3G8U9

pH 7.5, 25°C

752712

0.00026

N-(4-aminobutyl)-2-chloroethanimidamide

Streptococcus mutans

-

pH 8.0, 37°C

718884

0.00087

N-(4-aminobutyl)-2-chloroethanimidamide

Helicobacter pylori

-

pH 8.0, 37°C

718884

0.015

N-(4-aminobutyl)-2-chloroethanimidamide

Porphyromonas gingivalis

-

pH 8.0, 37°C

718884

0.0068

N-(4-aminobutyl)-2-fluoro-ethanimidamide

Helicobacter pylori

Q9ZN18

wild-type, pH 8.0, 37°C

711375

0.146

N-(4-aminobutyl)-2-fluoro-ethanimidamide

Listeria monocytogenes serotype 1/2a

A0A0H3G8U9

pH 7.5, 25°C

752712

0.00027

N-(4-aminobutyl)-2-fluoroethanimidamide

Streptococcus mutans

-

pH 8.0, 37°C

718884

0.0068

N-(4-aminobutyl)-2-fluoroethanimidamide

Helicobacter pylori

-

pH 8.0, 37°C

718884

0.091

N-(4-aminobutyl)-2-fluoroethanimidamide

Porphyromonas gingivalis

-

pH 8.0, 37°C

718884

0.03

Zn2+

Helicobacter pylori

Q9ZN18

wild-type, pH 8.0, 37°C

711375

0.25

Zn2+

Listeria monocytogenes

-

at 25°C and pH 7.5

734228