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3.5.1.B15: pyrazinamidase

This is an abbreviated version!
For detailed information about pyrazinamidase, go to the full flat file.

Word Map on EC 3.5.1.B15

Reaction

Pyrazinamide
+
H2O
=
pyrazinoic acid
 +
NH3

Synonyms

ASAC_0847, BsPncA, More, nicotinamidase/pyrazinamidase, PH0999, PncA, PolyNic, pyrazinamidase, pyrazinamidase/nicotinamidase, PZAase, PZAse

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.B15 pyrazinamidase

General Stability

General Stability on EC 3.5.1.B15 - pyrazinamidase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
kinetics of activation and half-life of wild-type and mutant PZases
-
stability and structure of recombinant pyrazinamidase (PZase) from Mycobacterium tuberculosis in alcohols, i.e. methanol, ethanol, isopropanol and n-propanol, are analyzed in the presence of absence of stabilizing osmolytes, sorbitol, sucrose and glycerol, overview. Methanol destabilizes, while glacerol stabilizes the enzyme. A decrease in the tertiary structure of the enzyme is less in the presence of ethanol, compared to the solutions of other alcohols. These results indicate that methanol, isopropanol and n-propanol decrease the tertiary structure of PZase in a similar manner