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3.5.1.B15: pyrazinamidase

This is an abbreviated version!
For detailed information about pyrazinamidase, go to the full flat file.

Word Map on EC 3.5.1.B15

Reaction

Pyrazinamide
+
H2O
=
pyrazinoic acid
+
NH3

Synonyms

ASAC_0847, BsPncA, More, nicotinamidase/pyrazinamidase, PH0999, PncA, PolyNic, pyrazinamidase, pyrazinamidase/nicotinamidase, PZAase, PZAse

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.B15 pyrazinamidase

Activating Compound

Activating Compound on EC 3.5.1.B15 - pyrazinamidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
glycerol
increases the enzyme activity up to 130% at 37°C, gives rise to an increase in the content of alpha-helix and beta-sheets elements. More stability of PZase in glycerol solution correlates with its amphiphilic orientation, which decreases the unfavorable interactions of hydrophobic regions.
sorbitol
increases the enzyme activity up to 110% at 37°C, gives rise to an increase in the content of alpha-helix and beta-sheets elements