3.5.1.B15: pyrazinamidase
This is an abbreviated version!
For detailed information about pyrazinamidase, go to the full flat file.
Word Map on EC 3.5.1.B15
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3.5.1.B15
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tuberculosis
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mycobacterium
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pzase
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pyrazinoic
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pza-resistant
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bactec
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pyrazinamide-resistant
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enterocolitica
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wayne
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mdr-tb
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middlebrooks
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autoagglutination
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pza-susceptible
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kristensenii
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kansasii
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diagnostics
- 3.5.1.B15
- tuberculosis
- mycobacterium
- pzase
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pyrazinoic
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pza-resistant
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bactec
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pyrazinamide-resistant
- enterocolitica
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wayne
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mdr-tb
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middlebrooks
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autoagglutination
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pza-susceptible
- kristensenii
- kansasii
- diagnostics
Reaction
Synonyms
ASAC_0847, BsPncA, More, nicotinamidase/pyrazinamidase, PH0999, PncA, PolyNic, pyrazinamidase, pyrazinamidase/nicotinamidase, PZAase, PZAse
ECTree
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Substrates Products
Substrates Products on EC 3.5.1.B15 - pyrazinamidase
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REACTION DIAGRAM
nicotinamide + H2O
nicotinate + NH3
binding structure involving residues A155, C159, and Ile154, and unbinding mechanism, modeling, overview
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pyrazinoic acid + NH3
the enzyme also catalyzes the hydrolysis of nicotinamide
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pyrazinamide + H2O
pyrazinoic acid + NH3
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the enzyme also catalyzes the hydrolysis of nicotinamide
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pyrazinamide + H2O
pyrazinoic acid + NH3
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a nicotinamide prodrug. In Mycobacterium tuberculosis the enzyme converts the nicotinamide analogue prodrug pyrazinamide into the bacteriostatic pyrazinoic acid
a bacteriostatic drug
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pyrazinamide + H2O
pyrazinoic acid + NH3
enzyme protein ligand interaction, docking study using the wild-type PncA protein structure (PDB ID 3PL1), overview
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pyrazinamide + H2O
pyrazinoic acid + NH3
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pyrazinamide + H2O
pyrazinoic acid + NH3
enzyme protein ligand interaction, docking study using the wild-type PncA protein structure (PDB ID 3PL1), overview
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pyrazinamide + H2O
pyrazinoic acid + NH3
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pyrazinamide + H2O
pyrazinoic acid + NH3
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pyrazinamide + H2O
pyrazinoic acid + NH3
enzyme protein ligand interaction, docking study using the wild-type PncA protein structure (PDB ID 3PL1), overview
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pyrazinamide + H2O
pyrazinoic acid + NH3
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colorimetric assay using ferrous ammonium sulfate 20% and glycine-HCl
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additional information
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colorimetric assay using ferrous ammonium sulfate 20% and glycine-HCl
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additional information
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docking study of PZA in the binding pocket of PZase
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additional information
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docking study of PZA in the binding pocket of PZase
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additional information
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colorimetric assay using ferrous ammonium sulfate 20% and glycine-HCl
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additional information
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docking study of PZA in the binding pocket of PZase
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additional information
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colorimetric assay using ferrous ammonium sulfate 20% and glycine-HCl
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additional information
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docking study of PZA in the binding pocket of PZase
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additional information
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colorimetric assay using ferrous ammonium sulfate 20% and glycine-HCl
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