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3.5.1.124: protein deglycase

This is an abbreviated version!
For detailed information about protein deglycase, go to the full flat file.

Word Map on EC 3.5.1.124

Reaction

an N6-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine
+
H2O
=
a [protein]-L-lysine
 +
Lactate

Synonyms

deglycase, DJ-1, DJ-1 deglycase, DJ-1 protein, glutathione-independent glyoxalase, glyoxalase, glyoxylase III, hchA, Hsp31, Maillard deglycase, More, PARK7, Parkinsonism-associated protein, Parkinsonism-associated protein DJ-1, PfpI, yajL, yhbO

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.124 protein deglycase

Systematic Name

Systematic Name on EC 3.5.1.124 - protein deglycase

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SYSTEMATIC NAME
IUBMB Comments
a [protein]-L-amino acid-1-hydroxypropan-2-one hydrolase [(R)-lactate-forming]
The enzyme, previously thought to be a glyoxalase, acts on glycated L-arginine, L-lysine, and L-cysteine residues within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. The attack forms hemithioacetal in the case of cysteines and aminocarbinols in the case of arginines and lysines. The enzyme repairs the amino acids, releasing glycolate or lactate (70-80% (S)-lactate and 20-30% (R)-lactate), depending on whether the attacking agent was glyoxal or 2-oxopropanal, respectively [3,4].