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3.5.1.124: protein deglycase

This is an abbreviated version!
For detailed information about protein deglycase, go to the full flat file.

Word Map on EC 3.5.1.124

Reaction

an N6-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine
+
H2O
=
a [protein]-L-lysine
 +
Lactate

Synonyms

deglycase, DJ-1, DJ-1 deglycase, DJ-1 protein, glutathione-independent glyoxalase, glyoxalase, glyoxylase III, hchA, Hsp31, Maillard deglycase, More, PARK7, Parkinsonism-associated protein, Parkinsonism-associated protein DJ-1, PfpI, yajL, yhbO

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.124 protein deglycase

Engineering

Engineering on EC 3.5.1.124 - protein deglycase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C106S
site-directed mutagenesis, inactive mutant
C46S
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
C53S
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
C188A
immeasurable glyoxalase activity
E79A
immeasurable glyoxalase activity
H158A
reduced amidopeptidase activity, glyoxalase activity is 53% compared to wild-type enzyme
H189A
immeasurable glyoxalase activity
H76A
immeasurable glyoxalase activity
Y224A
C188A
-
immeasurable glyoxalase activity
-
E79A
-
immeasurable glyoxalase activity
-
H158A
-
reduced amidopeptidase activity, glyoxalase activity is 53% compared to wild-type enzyme
-
H189A
-
immeasurable glyoxalase activity
-
H76A
-
immeasurable glyoxalase activity
-
additional information