3.4.24.B39: metallo-alpha-fibrinogenase
This is an abbreviated version!
For detailed information about metallo-alpha-fibrinogenase, go to the full flat file.
Word Map on EC 3.4.24.B39
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3.4.24.B39
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ligases
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squalene
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3-hydroxy-3-methyl-glutaryl
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hmgcr
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er-associated
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cholesterol-dependent
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misfolded
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sterol
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medicine
- 3.4.24.B39
-
ligases
- squalene
-
3-hydroxy-3-methyl-glutaryl
- hmgcr
-
er-associated
-
cholesterol-dependent
-
misfolded
- sterol
- medicine
Reaction
The enzymes cleaves the Aalpha-chain of fibrinogen with high specificity =
Synonyms
alpha-FG, alpha-Fibrinogenase, DAnase, fibrinogenase, rFII
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Inhibitors
Inhibitors on EC 3.4.24.B39 - metallo-alpha-fibrinogenase
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dithiothreitol
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incubation with 5 mM dithiothreitol results in 34% inhibition of azocasein hydrolysis
tris-(2-carboxyethyl)phosphine hydrochloride
complete inhibition at 1 mM
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aprotinin, and trypsin inhibitor SBTI do not affect the enzymatic activity
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additional information
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not inhibited by phenylmethylsulfonyl fluoride (10 mM) and STI (1 mg/ml)
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