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Literature summary for 3.4.24.B39 extracted from
- Isolation and characteristics of alpha-fibrinogenase venom from Naja oxiana (2013), Chem. Nat. Compd., 49, 712-715.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | complete inhibition at 10 mM | Naja oxiana |  |
| additional information | not inhibited by phenylmethylsulfonyl fluoride (10 mM) and STI (1 mg/ml) | Naja oxiana |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
x * 60000, SDS-PAGE | Naja oxiana |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Human fibrinogen + H2O | Naja oxiana | the enzyme cleaves dose-dependently the Aalpha-chain of human fibrinogen only. The enzyme cleaves a peptide with molecular weight of around 10 kDa from the C-terminus | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Naja oxiana | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Naja oxiana | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Human fibrinogen + H2O | the enzyme cleaves dose-dependently the Aalpha-chain of human fibrinogen only. The enzyme cleaves a peptide with molecular weight of around 10 kDa from the C-terminus | Naja oxiana | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 60000, SDS-PAGE | Naja oxiana |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-FG | - |
Naja oxiana |
| alpha-Fibrinogenase | - |
Naja oxiana |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | 40 | - |
Naja oxiana |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
heating for 15 min at 60°C leads to an activity loss of 80-85% | Naja oxiana |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 8 | - |
Naja oxiana |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Naja oxiana | isoelectric focusing | - |
10 |
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