3.4.24.B19: i-AAA protease
This is an abbreviated version!
For detailed information about i-AAA protease, go to the full flat file.
Word Map on EC 3.4.24.B19
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3.4.24.B19
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intermembrane
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xiap
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survivin
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proteostasis
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dynamin-like
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degradation
- 3.4.24.B19
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intermembrane
- xiap
- survivin
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proteostasis
-
dynamin-like
- degradation
Reaction
proteolytic degradation of proteins =
Synonyms
AAA protease, casein lytic proteinase XP, ClpXP, FtsH4, i-AAA Protease, IAP, IAP-1, M41.004, OSD1 protein, TAT-binding homolog 11, YME1, YME1 AAA protease, Yme1L, Yme1p
ECTree
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Cofactor
Cofactor on EC 3.4.24.B19 - i-AAA protease
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additional information
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no activity with beta-gamma-imidoadenosine 5'-phosphate, i.e. AMP-PNP
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ATP
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ATP binding is not necessary for enzyme assembly, enzyme contains conserved Walker-type ATPase domain of approximately 230 amino acids, dependent on, hydrolysis induces conformational changes
ATP
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dependent on, enzyme contains an ATPase domain with a Walker-type P-loop typical for the AAA protease family
ATP
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dependent on, enzyme contains an ATPase domain with a Walker-type P-loop typical for the AAA protease family, hydrolysis induces conformational changes of the AAA domain driving substrate unfolding and dislocation from the membrane
ATP
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required, contains ATP-binding site spanning from residues 316 to 328, GVLLTGPPGTGKT