3.4.24.B19: i-AAA protease
This is an abbreviated version!
For detailed information about i-AAA protease, go to the full flat file.
Word Map on EC 3.4.24.B19
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3.4.24.B19
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intermembrane
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xiap
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survivin
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proteostasis
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dynamin-like
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degradation
- 3.4.24.B19
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intermembrane
- xiap
- survivin
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proteostasis
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dynamin-like
- degradation
Reaction
proteolytic degradation of proteins =
Synonyms
AAA protease, casein lytic proteinase XP, ClpXP, FtsH4, i-AAA Protease, IAP, IAP-1, M41.004, OSD1 protein, TAT-binding homolog 11, YME1, YME1 AAA protease, Yme1L, Yme1p
ECTree
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Localization
Localization on EC 3.4.24.B19 - i-AAA protease
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integral, catalytic site facing the intermembrane space
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integral, a large domain is exposed to the intermembrane space
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integral, catalytic site facing the intermembrane space
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only subunit type Yme1p spans the membrane once, integral, catalytic site facing the inter membrane space
stomatin-like protein localizes to the mitochondrial inner membrane and anchors a large protease complex composed of the rhomboid protease PARL and the i-AAA protease YME1L. Association with SLP2 in the SPY complex regulates PARL-mediated processing of PTEN-induced kinase PINK1 and the phosphatase PGAM5 in mitochondria
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inner mitochondrial membrane, oriented toward the intermembrane space
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tightly associated with the inner mitochondrial membrane, oriented with the bulk of the protein facing the matrix
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Yme1p is associated with the Mgr1 protein in mitochondria