3.4.24.87: ADAMTS13 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS13 endopeptidase, go to the full flat file.

Reaction

The enzyme cleaves the von Willebrand factor at bond Tyr842-/-Met843 within the A2 domain =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs 13, a disintegrin and metalloprotease with thrombospondin type 1 repeats 13, a disintegrin and metalloprotease with thrombospondin-13, a disintegrin and metalloproteinase with a thrombonspondin type 1 motif member 13, a disintegrin and metalloproteinase with a thrombospondin motif repeats 13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13, a disintegrin-like and metalloprotease with thrombospondin type I repeats � 13, a disintegrin-like and metalloprotease with thrombospondin type-1 motifs 13, a disintegrin-like and metalloproteinase domain with thrombospondin type I motifs 13, a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13, a disintegrin-like domain and metalloprotease with thrombospondin type I motif, a thrombospondin type 1 motif, member 13, ADAMTS 13, ADAMTS VWF cleaving metalloprotease, ADAMTS-13, ADAMTS13, ADAMTS13 metalloprotease, M12.241, metalloprotease ADAMTS-13, More, plasma metalloprotease ADAMTS13, plasma von Willebrand factor cleaving activity, Upshaw factor, van Willebrand factor processing activity, von Willebrand cleavage protease, von Willebrand cleavaging protease, von Willebrand factor cleaving protease, von Willebrand factor specific cleaving protease, von Willebrand factor-cleaving metalloprotease, von Willebrand factor-cleaving protease, von Willebrand factor-cleaving proteinase, von-Willebrand factor cleaving protease, von-Willebrand factor degrading protease, von-Willebrand-factor-cleaving protease, VWF cleaving metalloprotease, VWF cleaving protease, vWF protease, VWF-cleaving metalloprotease, vWF-cleaving protease, VWF-CP, vWF-degrading protease, VWFCP, xWF-CP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.87 ADAMTS13 endopeptidase

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Results	in table
19	Activating Compound
5	AA Sequence
23	Application
1	CAS Registry Number
46	Cloned(Commentary)
3	Crystallization (Commentary)
7770	Disease/ Diagnostics
2	Expression
74	General Information
2	General Stability
1	IC50 Value
57	Inhibitors
18	kcat/KM [mM/s]
3	Ki Value [mM]
28	KM Value [mM]
70	Localization
75	Metals/Ions
13	Molecular Weight [Da]
128	Natural Substrates/ Products (Substrates)
200	Organism
4	PDB ID
33	pH Optimum
1	pH Stability
1	pI Value
11	Posttranslational Modification
169	Protein Variants
21	Purification (Commentary)
6	Reaction
12	Reaction Type
145	Reference
181	Source Tissue
4	Specific Activity [micromol/min/mg]
240	Substrates and Products (Substrate)
20	Subunits
224	Synonyms
27	Temperature Optimum [°C]
2	Temperature Stability [°C]
22	Turnover Number [1/s]

Sequence

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Sequence on EC 3.4.24.87 - ADAMTS13 endopeptidase

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTIONThe reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

Q76LX8 pBLAST

ATS13_HUMAN

Homo sapiens

1427

1

153604

Swiss-Prot

Show Sequence

Secretory Pathway (Reliability: 2)

Q769J6 pBLAST

ATS13_MOUSE

Mus musculus

1426

1

155357

Swiss-Prot

Show Sequence

Secretory Pathway (Reliability: 3)

A0A6J8C7I2 pBLAST

A0A6J8C7I2_MYTCO

Mytilus coruscus

1546

0

171067

TrEMBL

Show Sequence

Secretory Pathway (Reliability: 3)

A0A6J8ECQ0 pBLAST

A0A6J8ECQ0_MYTCO

Mytilus coruscus

616

0

69443

TrEMBL

Show Sequence

Mitochondrion (Reliability: 5)

A0A8B6BYS9 pBLAST

A0A8B6BYS9_MYTGA

Mytilus galloprovincialis

562

0

63142

TrEMBL

Show Sequence

other Location (Reliability: 1)

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