3.4.24.87: ADAMTS13 endopeptidase

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For detailed information about ADAMTS13 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.87

3.4.24.87

thrombotic

thrombocytopenic

purpura

ttp

platelet

multimers

hemolytic

anemia

endothelial

metalloproteinase

autoantibody

microangiopathic

rituximab

remission

uremic

microvascular

relapse

life-threatening

shear

idiopathic

coagulation

autoimmune

thrombi

bleeding

hemostasis

schistocytes

intravascular

relapsing

plasmapheresis

ultra-large

hemostat

disintegrin-like

microcirculation

vwf:ag

coombs

plasmic

microthrombi

shiga

hellp

collagen-binding

antiphospholipid

microthrombosis

d-dimers

fviii

prothrombotic

apheresis

hemolytic-uremic

ristocetin

eculizumab

medicine

oklahoma

analysis

drug development

diagnostics

Reaction

The enzyme cleaves the von Willebrand factor at bond Tyr842-/-Met843 within the A2 domain =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs 13, a disintegrin and metalloprotease with thrombospondin type 1 repeats 13, a disintegrin and metalloprotease with thrombospondin-13, a disintegrin and metalloproteinase with a thrombonspondin type 1 motif member 13, a disintegrin and metalloproteinase with a thrombospondin motif repeats 13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13, a disintegrin-like and metalloprotease with thrombospondin type I repeats � 13, a disintegrin-like and metalloprotease with thrombospondin type-1 motifs 13, a disintegrin-like and metalloproteinase domain with thrombospondin type I motifs 13, a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13, a disintegrin-like domain and metalloprotease with thrombospondin type I motif, a thrombospondin type 1 motif, member 13, ADAMTS 13, ADAMTS VWF cleaving metalloprotease, ADAMTS-13, ADAMTS13, ADAMTS13 metalloprotease, M12.241, metalloprotease ADAMTS-13, More, plasma metalloprotease ADAMTS13, plasma von Willebrand factor cleaving activity, Upshaw factor, van Willebrand factor processing activity, von Willebrand cleavage protease, von Willebrand cleavaging protease, von Willebrand factor cleaving protease, von Willebrand factor specific cleaving protease, von Willebrand factor-cleaving metalloprotease, von Willebrand factor-cleaving protease, von Willebrand factor-cleaving proteinase, von-Willebrand factor cleaving protease, von-Willebrand factor degrading protease, von-Willebrand-factor-cleaving protease, VWF cleaving metalloprotease, VWF cleaving protease, vWF protease, VWF-cleaving metalloprotease, vWF-cleaving protease, VWF-CP, vWF-degrading protease, VWFCP, xWF-CP

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.87 ADAMTS13 endopeptidase

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Results	in table
19	Activating Compound
5	AA Sequence
23	Application
1	CAS Registry Number
46	Cloned(Commentary)
3	Crystallization (Commentary)
7770	Disease/ Diagnostics
2	Expression
74	General Information
2	General Stability
1	IC50 Value
57	Inhibitors
18	kcat/KM [mM/s]
3	Ki Value [mM]
28	KM Value [mM]
70	Localization
75	Metals/Ions
13	Molecular Weight [Da]
128	Natural Substrates/ Products (Substrates)
200	Organism
4	PDB ID
33	pH Optimum
1	pH Stability
1	pI Value
11	Posttranslational Modification
169	Protein Variants
21	Purification (Commentary)
6	Reaction
12	Reaction Type
145	Reference
181	Source Tissue
4	Specific Activity [micromol/min/mg]
240	Substrates and Products (Substrate)
20	Subunits
224	Synonyms
27	Temperature Optimum [°C]
2	Temperature Stability [°C]
22	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.24.87 - ADAMTS13 endopeptidase

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150000

150000 - 190000

gel filtration

170000

180000

x * 180000, SDS-PAGE

190000

195000

SDS-PAGE

300000

gel filtration

45000

x * 45000, recombinant His-tagged ADAMTS13 ancillary domains, ADAMTS13-DTCS, SDS-PAGE

710732