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3.4.24.87: ADAMTS13 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS13 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.87

Reaction

The enzyme cleaves the von Willebrand factor at bond Tyr842-/-Met843 within the A2 domain =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs 13, a disintegrin and metalloprotease with thrombospondin type 1 repeats 13, a disintegrin and metalloprotease with thrombospondin-13, a disintegrin and metalloproteinase with a thrombonspondin type 1 motif member 13, a disintegrin and metalloproteinase with a thrombospondin motif repeats 13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13, a disintegrin-like and metalloprotease with thrombospondin type I repeats – 13, a disintegrin-like and metalloprotease with thrombospondin type-1 motifs 13, a disintegrin-like and metalloproteinase domain with thrombospondin type I motifs 13, a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13, a disintegrin-like domain and metalloprotease with thrombospondin type I motif, a thrombospondin type 1 motif, member 13, ADAMTS 13, ADAMTS VWF cleaving metalloprotease, ADAMTS-13, ADAMTS13, ADAMTS13 metalloprotease, M12.241, metalloprotease ADAMTS-13, More, plasma metalloprotease ADAMTS13, plasma von Willebrand factor cleaving activity, Upshaw factor, van Willebrand factor processing activity, von Willebrand cleavage protease, von Willebrand cleavaging protease, von Willebrand factor cleaving protease, von Willebrand factor specific cleaving protease, von Willebrand factor-cleaving metalloprotease, von Willebrand factor-cleaving protease, von Willebrand factor-cleaving proteinase, von-Willebrand factor cleaving protease, von-Willebrand factor degrading protease, von-Willebrand-factor-cleaving protease, VWF cleaving metalloprotease, VWF cleaving protease, vWF protease, VWF-cleaving metalloprotease, vWF-cleaving protease, VWF-CP, vWF-degrading protease, VWFCP, xWF-CP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.87 ADAMTS13 endopeptidase

Source Tissue

Source Tissue on EC 3.4.24.87 - ADAMTS13 endopeptidase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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a renal carcinoma cell line
Manually annotated by BRENDA team
in cerebral corpora amylacea, that occur in aging brains and in patients with neurodegenerative conditions
Manually annotated by BRENDA team
in astrocytes of aging brains and patients with neurodegenerative conditions. Corporae amylaceae include glycosylated material, ubiquitin, and an assortment of proteins derived from neuronal cytoplasm. Many of these proteins are not specifically localized to neurons or astrocytes, some components of corpora amylacea, such as complement proteins, are most abundantly expressed outside the central nervous system. Corporae amylaceae can result from a conglomeration of interacting proteins from degenerating neurons and from extravasated blood elements released after transient breakdown of the blood-brain barrier
Manually annotated by BRENDA team
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primary renal cortical cell cultures, real-time PCR and immunohistochemic analysis, overview
Manually annotated by BRENDA team
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ADAMTS13 and von Willebrand factor contents, overview
Manually annotated by BRENDA team
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ADAMTS13 and von Willebrand factor contents, overview
Manually annotated by BRENDA team
enzyme expression
Manually annotated by BRENDA team
thrombospondin1 and ADAMTS13 form complexes together in cells and in direct protein binding assays
Manually annotated by BRENDA team
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secretes the enzyme
Manually annotated by BRENDA team
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in both proximal and distal in healthy persons and in patients with renal disorders, e.g. tubulopathy
Manually annotated by BRENDA team
enzyme expression
Manually annotated by BRENDA team
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at the surface of endothelial cells
Manually annotated by BRENDA team
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only in urine from patients with renal disorder tubulopathy
Manually annotated by BRENDA team
additional information