3.4.24.84: Ste24 endopeptidase
This is an abbreviated version!
For detailed information about Ste24 endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.84
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3.4.24.84
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lamins
-
prelamin
-
progeroid
-
farnesylated
-
hutchinson-gilford
-
metalloprotease
-
laminopathies
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dermopathy
-
lipodystrophy
-
mandibuloacral
-
farnesyltransferase
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clavicles
-
misshapen
-
ste14p
-
acro-osteolysis
-
carboxylmethylation
-
micrognathia
-
medicine
- 3.4.24.84
- lamins
-
prelamin
-
progeroid
-
farnesylated
-
hutchinson-gilford
- metalloprotease
- laminopathies
-
dermopathy
- lipodystrophy
-
mandibuloacral
-
farnesyltransferase
-
clavicles
-
misshapen
-
ste14p
- acro-osteolysis
-
carboxylmethylation
- micrognathia
- medicine
Reaction
The peptide bond hydrolysed can be designated -C-/-aaX in which C is an S-isoprenylated cysteine residue, a is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids =
Synonyms
a-factor converting enzyme, Afc1, Afc1p, At Ste24p, AtSte24, CAAX prenyl protease 1 homolog, FACE-1, Hs Ste24p, Sc Ste24p, Ste24p, Zmpste24
ECTree
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Reference on EC 3.4.24.84 - Ste24 endopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fujimura-Kamada, K.; Nouvet, F.J.; Michaelis, S.
A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor
J. Cell Biol.
136
271-285
1997
Saccharomyces cerevisiae
Tam, A.; Nouvet, F.J.; Fujimura-Kamada, K.; Slunt, H.; Sisodia, S.S.; Michaelis, S.
Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing
J. Cell Biol.
142
635-649
1998
Saccharomyces cerevisiae, Homo sapiens
Schmidt, W.K.; Tam, A.; Fujimura-Kamada, K.; Michaelis, S.
Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage
Proc. Natl. Acad. Sci. USA
95
11175-11180
1998
Saccharomyces cerevisiae
Schmidt, W.K.; Tam, A.; Michaelis, S.
Reconstitution of the Ste24p-dependent N-terminal proteolytic step in yeast a-factor biogenesis
J. Biol. Chem.
275
6227-6233
2000
Saccharomyces cerevisiae, Homo sapiens
Tam, A.; Schmidt, W.K.; Michaelis, S.
The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor
J. Biol. Chem.
276
46798-46806
2001
Saccharomyces cerevisiae
Bracha, K.; Lavy, M.; Yalovsky, S.
The Arabidopsis AtSTE24 is a CAAX protease with broad substrate specificity
J. Biol. Chem.
277
29856-29864
2002
Homo sapiens (O75844), Saccharomyces cerevisiae (P47154), Saccharomyces cerevisiae, Arabidopsis thaliana (Q8RX88)
Boyartchuk, V.L.; Rine, J.
Roles pf prenyl protein proteases in maturation of Saccharomyces cerevisiae
Genetics
150
95-1001
1998
Saccharomyces cerevisiae
Leung, G.K.; Schmidt, W.K.; Bergo, M.O.; Gavino, B.; Wong, D.H.; Tam, A.; Ashby, M.N.; Michaelis, S.; Young, S.G.
Biochemical studies of Zmpste24-deficient mice
J. Biol. Chem.
276
29051-29058
2001
Mus musculus (Q80W54), Mus musculus
Trueblood, C.E.; Boyartchuk, V.L.; Picologlou, E.A.; Rozema, D.; Poulter, C.D.; Rine, J.
The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities
Mol. Cell. Biol.
20
4381-4392
2000
Saccharomyces cerevisiae
Boyartchuk.V.L.; Ashby, M.N.; Rine, J.
Modulation of Ras and a-factor function by carboxyl-terminal proteolysis
Science
275
1796-1800
1997
Saccharomyces cerevisiae (P47154)
Pei, J.; Grishin, N.V.
Type II CAAX prenyl endopeptidases belong to a novel superfamily of putative membrane-bound metalloproteases
Trends Biochem. Sci.
26
275-277
2001
Saccharomyces cerevisiae
Corrigan, D.P.; Kuszczak, D.; Rusinol, A.E.; Thewke, D.P.; Hrycyna, C.A.; Michaelis, S.; Sinensky, M.S.
Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24
Biochem. J.
387
129-138
2005
Homo sapiens
Moulson, C.L.; Go, G.; Gardner, J.M.; van der Wal, A.C.; Smitt, J.H.; van Hagen, J.M.; Miner, J.H.
Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy
J. Invest. Dermatol.
125
913-919
2005
Homo sapiens
Varela, I.; Cadinanos, J.; Pendas, A.M.; Gutierrez-Fernandez, A.; Folgueras, A.R.; Sanchez, L.M.; Zhou, Z.; Rodriguez, F.J.; Stewart, C.L.; Vega, J.A.; Tryggvason, K.; Freije, J.M.; Lopez-Otin, C.
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Nature
437
564-568
2005
Mus musculus
Porter, S.B.; Hildebrandt, E.R.; Breevoort, S.R.; Mokry, D.Z.; Dore, T.M.; Schmidt, W.K.
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones
Biochim. Biophys. Acta
1773
853-862
2007
Arabidopsis thaliana, Saccharomyces cerevisiae, Homo sapiens
Coffinier, C.; Hudson, S.E.; Farber, E.A.; Chang, S.Y.; Hrycyna, C.A.; Young, S.G.; Fong, L.G.
HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells
Proc. Natl. Acad. Sci. USA
104
13432-13437
2007
Mus musculus
Smigiel, R.; Jakubiak, A.; Esteves-Vieira, V.; Szela, K.; Halon, A.; Jurek, T.; Levy, N.; De Sandre-Giovannoli, A.
Novel frameshifting mutations of the ZMPSTE24 gene in two siblings affected with restrictive dermopathy and review of the mutations described in the literature
Am. J. Med. Genet. A
152A
447-452
2010
Homo sapiens
Rivas, D.; Li, W.; Akter, R.; Henderson, J.E.; Duque, G.
Accelerated features of age-related bone loss in zmpste24 metalloproteinase-deficient mice
J. Gerontol. A Biol. Sci. Med. Sci.
64
1015-1024
2009
Mus musculus
Goulbourne, C.N.; Vaux, D.J.
HIV protease inhibitors inhibit FACE1/ZMPSTE24: a mechanism for acquired lipodystrophy in patients on highly active antiretroviral therapy?
Biochem. Soc. Trans.
38
292-296
2010
Homo sapiens (O75844), Homo sapiens
Ahmad, Z.; Phadke, S.R.; Arch, E.; Glass, J.; Agarwal, A.K.; Garg, A.
Homozygous null mutations in ZMPSTE24 in restrictive dermopathy: evidence of genetic heterogeneity
Clin. Genet.
81
158-164
2012
Homo sapiens (O75844)
Barrowman, J.; Hamblet, C.; Kane, M.; Michaelis, S.
Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24
PLoS ONE
7
e32120
2012
Homo sapiens (O75844), Homo sapiens
Spear, E.D.; Hsu, E.T.; Nie, L.; Carpenter, E.P.; Hrycyna, C.A.; Michaelis, S.
ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability
Dis. Model. Mech.
11
dmm033670
2018
Homo sapiens (O75844), Homo sapiens
Hildebrandt, E.R.; Arachea, B.T.; Wiener, M.C.; Schmidt, W.K.
Ste24p mediates proteolysis of both isoprenylated and non-prenylated oligopeptides
J. Biol. Chem.
291
14185-14198
2016
Saccharomyces mikatae
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