3.4.24.84: Ste24 endopeptidase

This is an abbreviated version!
For detailed information about Ste24 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.84

3.4.24.84

lamins

prelamin

progeroid

farnesylated

hutchinson-gilford

metalloprotease

laminopathies

dermopathy

lipodystrophy

mandibuloacral

farnesyltransferase

clavicles

misshapen

ste14p

acro-osteolysis

carboxylmethylation

micrognathia

medicine

Reaction

The peptide bond hydrolysed can be designated -C-/-aaX in which C is an S-isoprenylated cysteine residue, a is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids =

Synonyms

a-factor converting enzyme, Afc1, Afc1p, At Ste24p, AtSte24, CAAX prenyl protease 1 homolog, FACE-1, Hs Ste24p, Sc Ste24p, Ste24p, Zmpste24

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.84 Ste24 endopeptidase

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Results	in table
3985	AA Sequence
4	Application
1	CAS Registry Number
10	Cloned(Commentary)
1	Crystallization (Commentary)
289	Disease/ Diagnostics
4	General Information
2	IC50 Value
18	Inhibitors
5	Ki Value [mM]
7	KM Value [mM]
13	Localization
14	Metals/Ions
3	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
30	Organism
2	Pathway
13	PDB ID
34	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
30	Reference
9	Source Tissue
1	Specific Activity [micromol/min/mg]
46	Substrates and Products (Substrate)
2	Subunits
25	Synonyms

Inhibitors

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Inhibitors on EC 3.4.24.84 - Ste24 endopeptidase

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1,10-phenanthroline

Zn2+ chelator

atazanavir

benzyloxycarbonyl-Phe-Ala-2,4,6-trimethylbenzoyloxymethyl ketone

3 entries

benzyloxycarbonyl-Phe-Lys-2,4,6-trimethylbenzoyloxymethyl ketone

darunavir

lopinavir

lovastatin

abolishes the conversion of prelamin A into lamin A

o-phenanthroline

ritonavir

tipranavir

additional information

2 entries