3.4.24.66: choriolysin L

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For detailed information about choriolysin L, go to the full flat file.

Reaction

Hydrolysis of the inner layer of fish egg envelope. Also hydrolysis of casein and small molecule substrates such as succinyl-Leu-Leu-Val-Tyr-/-7-(4-methyl)coumarylamide =

Synonyms

choriolysin L, chorionase, EHE, embryo-specific hatching enzyme, FLCE, LCE, Low choriolytic enzyme, medaka hatching enzyme, medaka low choriolytic enzyme, MLCE, More, Teleost hatching enzyme (component)

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.66 choriolysin L

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Results	in table
1	AA Sequence
2	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Expression
2	General Information
4	Inhibitors
1	KM Value [mM]
3	Localization
8	Metals/Ions
4	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
12	Organism
5	pH Optimum
1	pH Range
5	Purification (Commentary)
1	Reaction
1	Reaction Type
12	Reference
18	Source Tissue
1	Specific Activity [micromol/min/mg]
32	Substrates and Products (Substrate)
2	Subunits
23	Synonyms
2	Temperature Optimum [°C]

General Information

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General Information on EC 3.4.24.66 - choriolysin L

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

no activity in Hippocampus abdominalis

-

only gene expression of high choriolytic enzyme (HCE) and not of low choriolytic enzyme (LCE),is detected. The seahorse LCE gene is pseudogenized during evolution

754301

physiological function

Rhabdoblennius nitidus

-

the egg envelope is cooperatively solubilized by high choriolytic enzyme (HCE) and low choriolytic enzyme (LCE). High choriolytic enzyme swells the intact egg envelope, and then low choriolytic enzyme solubilizes the swollen envelope. The lower expression level of LCE but also different components of the egg-envelope protein result in an inefficient hatching enzyme/egg-envelope digestion system in this species

754302