3.4.24.58: russellysin

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For detailed information about russellysin, go to the full flat file.

Reaction

Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg-/- bonds. Has no action on insulin B chain =

Synonyms

Blood-coagulation factor X activating enzyme, EC 3.4.21.23, Metalloproteinase RVV-x, Proteinase, Vipera russelli, Russell's viper blood coagulation factor X activator, Russell's Viper venom factor X activator, Russell's viper venom factor X activator, RVV-X, Russell`s viper venom coagulation factor X-activating enzyme, Russell�s viper venom factor X activator, RVV-X, snake venom protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.58 russellysin

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Results	in table
4	AA Sequence
2	Application
1	CAS Registry Number
1	Crystallization (Commentary)
6	Inhibitors
1	KM Value [mM]
2	Localization
7	Metals/Ions
8	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
8	Organism
1	PDB ID
2	pH Optimum
1	pH Range
3	Posttranslational Modification
3	Purification (Commentary)
1	Reaction
1	Reaction Type
8	Reference
7	Source Tissue
1	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
3	Subunits
16	Synonyms
1	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 3.4.24.58 - russellysin

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

EDTA

Protobothrops mucrosquamatus

-

-

668852

pyroGlu-Arg-Trp

Daboia siamensis

Q7LZ61; Q4PRD1; Q4PRD2

the synthetic tripeptide shows complete inhibition of the gelatinolytic activity of RVV-X at 5 mM

755612

pyroGlu-Glu-Trp

Daboia siamensis

Q7LZ61; Q4PRD1; Q4PRD2

the synthetic tripeptide shows complete inhibition of the gelatinolytic activity of RVV-X at 5 mM

755612

pyroGlu-Lys-Trp

Daboia siamensis

Q7LZ61; Q4PRD1; Q4PRD2

the synthetic tripeptide shows complete inhibition of the gelatinolytic activity of RVV-X at 5 mM

755612

RNA132

Daboia russelii

-

an allosteric RNA aptamer, secondary structure folding, overview, causes 87% inhibition of the enzyme in the RVV-X-SPZXa assay, using a chromogenic substrate for the activated factor X, releasing the chromophore, 4-nitroanilide acetate, the snake venom protease competes with the human or murine vascular endothelial growth factor, VEGF165, for binding to RNA132 and reverses the inhibitory activity of RNA132 on RVV-X and restores its enzymatic activity, the VEGF165 of zebrafish functions partially, mapping of binding sites, overview

683152

-

Snake venom factor IX/factor X-binding protein

Daboia russelii

-

with a C-type lectin structure, inhibits factor X activation

31350

-