3.4.24.3: microbial collagenase

This is an abbreviated version!
For detailed information about microbial collagenase, go to the full flat file.

Reaction

Digestion of native collagen in the triple helical region at -/-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3' =

Synonyms

120 kDa collagenase, Achromobacter iophagus collagenase, aspergillopeptidase C, azocollase, bacterial collagenase, bacterial collagenase V, BC_2466, CCA, ChC, class I collagenase, class II collagenase, class III collagenase, clostridial collagenase, clostridial collagenase A, clostridiopeptidase A, clostridiopeptidase I, clostridiopeptidase II, Clostridium histolyticum class II collagenase, Clostridium histolyticum collagenase, ColA, ColG, ColH, collagen peptidase, collagen protease, collagenase, collagenase A, collagenase clostridium histolyticum, collagenase G, collagenase H, collagenase I, collagenase MMP-1, collagenase T, ColT, Dupuytren clostridium histolyticum, Dupuytren collagenase, EC 3.4.24.8, EC 3.4.4.19, EC 3.4.99.5, kollaza, M9-peptidase, matirx metalloproteinase-18, matrix metalloproteinase-1, metallocollagenase, metalloproteinase ColB, metalloproteinase-1, microbial collagenase, MMP-1, More, nucleolysin, peptidase, clostridio-, A, proteinase, Clostridium histolyticum, A, soycollagestin, thermophilic collagenolytic protease, type I collagenase, type II collagenase, VMC peptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.3 microbial collagenase

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Results	in table
1	Activating Compound
3231	AA Sequence
5	Application
1	CAS Registry Number
13	Cloned(Commentary)
11	Crystallization (Commentary)
4	Expression
41	General Information
3	General Stability
17	IC50 Value
392	Inhibitors
338	Ki Value [mM]
12	KM Value [mM]
7	Localization
37	Metals/Ions
62	Molecular Weight [Da]
78	Natural Substrates/ Products (Substrates)
113	Organism
29	PDB ID
19	pH Optimum
6	pH Range
3	pH Stability
3	Posttranslational Modification
18	Protein Variants
28	Purification (Commentary)
1	Reaction
1	Reaction Type
107	Reference
11	Source Tissue
10	Specific Activity [micromol/min/mg]
5	Storage Stability
253	Substrates and Products (Substrate)
50	Subunits
197	Synonyms
9	Temperature Optimum [°C]
13	Temperature Stability [°C]
6	Turnover Number [1/s]

Expression

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Expression on EC 3.4.24.3 - microbial collagenase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

colB exhibits a relatively stable low level expression. In the host condition, the expression of colB is continuously increased from the exponential phase to the later stationary phase. During the midexponential and stationary phases, colB exhibits significantly higher transcription levels in the host than in the LB condition, increasing by 121.5fold and 458.9fold respectively. Together, the expression and transcription analyses confirms that high levels of colB expression are induced in Bacillus thuringiensis in the intestine of infected Caenorhabditis elegans

2 entries

ColB expression is highly induced and regulated by the global activator PlcR

2 entries

colB exhibits a relatively stable low level expression. In the host condition, the expression of colB is continuously increased from the exponential phase to the later stationary phase. During the midexponential and stationary phases, colB exhibits significantly higher transcription levels in the host than in the LB condition, increasing by 121.5fold and 458.9fold respectively. Together, the expression and transcription analyses confirms that high levels of colB expression are induced in Bacillus thuringiensis in the intestine of infected Caenorhabditis elegans

Bacillus thuringiensis

-

753442

colB exhibits a relatively stable low level expression. In the host condition, the expression of colB is continuously increased from the exponential phase to the later stationary phase. During the midexponential and stationary phases, colB exhibits significantly higher transcription levels in the host than in the LB condition, increasing by 121.5fold and 458.9fold respectively. Together, the expression and transcription analyses confirms that high levels of colB expression are induced in Bacillus thuringiensis in the intestine of infected Caenorhabditis elegans

Bacillus thuringiensis YBT-1518

-

-

ColB expression is highly induced and regulated by the global activator PlcR

Bacillus thuringiensis

-

753442

ColB expression is highly induced and regulated by the global activator PlcR

Bacillus thuringiensis YBT-1518

-

-