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3.4.24.3: microbial collagenase

This is an abbreviated version!
For detailed information about microbial collagenase, go to the full flat file.

Word Map on EC 3.4.24.3

Reaction

Digestion of native collagen in the triple helical region at -/-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3' =

Synonyms

120 kDa collagenase, Achromobacter iophagus collagenase, aspergillopeptidase C, azocollase, bacterial collagenase, bacterial collagenase V, BC_2466, CCA, ChC, class I collagenase, class II collagenase, class III collagenase, clostridial collagenase, clostridial collagenase A, clostridiopeptidase A, clostridiopeptidase I, clostridiopeptidase II, Clostridium histolyticum class II collagenase, Clostridium histolyticum collagenase, ColA, ColG, ColH, collagen peptidase, collagen protease, collagenase, collagenase A, collagenase clostridium histolyticum, collagenase G, collagenase H, collagenase I, collagenase MMP-1, collagenase T, ColT, Dupuytren clostridium histolyticum, Dupuytren collagenase, EC 3.4.24.8, EC 3.4.4.19, EC 3.4.99.5, kollaza, M9-peptidase, matirx metalloproteinase-18, matrix metalloproteinase-1, metallocollagenase, metalloproteinase ColB, metalloproteinase-1, microbial collagenase, MMP-1, More, nucleolysin, peptidase, clostridio-, A, proteinase, Clostridium histolyticum, A, soycollagestin, thermophilic collagenolytic protease, type I collagenase, type II collagenase, VMC peptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.3 microbial collagenase

IC50 Value

IC50 Value on EC 3.4.24.3 - microbial collagenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.025 - 0.15
1,10-phenanthroline
0.035
cabozantinib
Hathewaya histolytica
-
IC50: 0.035 mM
0.415
erucic acid
Hathewaya histolytica
-
IC50: 0.415 mM
0.03
heptadecanoic acid
Hathewaya histolytica
-
IC50: 0.03 mM
0.375
linoleic acid
Hathewaya histolytica
-
IC50: 0.375 mM
0.46
linolenic acid
Hathewaya histolytica
-
IC50: 0.46 mM
0.27
myristic acid
Hathewaya histolytica
-
IC50: 0.27 mM
0.46
oleic acid
Hathewaya histolytica
-
IC50: 0.46 mM
0.405
palmitoleic acid
Hathewaya histolytica
-
IC50: 0.405 mM
0.125
pentadecanoic acid
Hathewaya histolytica
-
IC50: 0.125 mM
0.03
stearic acid
Hathewaya histolytica
-
IC50: 0.03 mM
0.5
additional information
Hathewaya histolytica
-
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid
-