3.4.24.12: envelysin
This is an abbreviated version!
For detailed information about envelysin, go to the full flat file.
Reaction
Hydrolysis of proteins of the fertilization envelope and dimethylcasein =
Synonyms
chorion-digesting proteinase, chorionase, chymostrypsin, Envelysin, hatching enzyme, HCE, HE, HEz, High choriolytic enzyme, LCE, Low choriolytic enzyme, proteinase, chorion-digesting, sea urchin embryo hatching enzyme, sea-urchin-hatching proteinase
ECTree
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Substrates Products on EC 3.4.24.12 - envelysin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr + H2O
Ala-Ser-Thr-Thr-Thr-Asn + Tyr-Thr
-
i.e. peptide T, partial cleavage at Asn6-Tyr7
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
Arg-Pro-Lys-Pro-Gln-Gln + Phe-Phe-Gly-Leu-Met-NH2
-
i.e. substance P
-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg
-
i.e. bradykinin, partial cleavage at Pro7-Phe8
-
?
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + H2O
Asp-Arg-Val-Tyr-Ile-His-Pro + Phe-His-Leu
-
i.e. angiotensin I, partial cleavage at Pro7-Phe8
-
?
benzyloxycarbonyl-Glu-Phe + H2O
benzyloxycarbonyl-Glu + Phe
-
-
-
-
?
Benzyloxycarbonyl-Glu-Tyr + H2O
Benzyloxycarbonyl-Glu + Tyr
-
-
-
-
?
egg envelope
?
-
proteolyzes the fertilization envelope, thereby allowing the embryo to hatch
-
-
?
Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2 + H2O
?
-
i.e. mastoparan, clevage sites: Asn2-Leu3, 100%, Ala7-Ala8, 100%, Ala10-Lys11, 47%, and Lys12-Ile13, 47%
-
-
?
insulin
?
-
oxidized B chain of insulin cleaved at FVNQ-HLCGSHLVEA-LY-LVCGERGFF-YTPKA
-
-
?
N-benzoyl-L-tyrosine ethyl ester + H2O
N-benzoyl-Tyr + ethanol
-
-
-
-
?
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys + H2O
Tyr-Gly-Gly-Phe + Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys
-
i.e. dynorphin A(1-13), partial cleavage at Phe4-Leu5
-
?
Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro + H2O
Tyr-Gly-Gly-Phe + Leu-Arg-Lys-Tyr-Pro
-
i.e. beta-neoendorphin, partial cleavage at Phe4-Leu5
-
?
fertilization envelope + H2O
?
-
enzyme exhibits a unique species specificity, it can not dissolve the fertilization envelope of Anthocidaris crassispina, a species of a neighboring taxonomical family, but can dissolve that of more distantly related species, even if with less efficiency
-
-
?
additional information
?
-
-
preferentially cleaves the peptide bond on the amino side of bulky hydrophobic residues, -Leu, -Ile, and -Phe as well as -Tyr
-
-
?
additional information
?
-
-
short proteolyzed envelysin lacking the C-terminal part preferentially cleaves peptide bonds on the amino side of hydrophobic bulky residues (-Leu,-Ile,-Phe,-Tyr)
-
-
?
