Application | Comment | Organism |
---|---|---|
degradation | one of the earliest zygotic genes activated, about 12-20 h after fertilization, the hatching enzyme is secreted, digesting the fertilization envelope and freeing the swimming blastula | Echinoidea |
molecular biology | Ets4 is one of the transcription factors that control HE expression | Strongylocentrotus purpuratus |
Cloned (Comment) | Organism |
---|---|
- |
Paracentrotus lividus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-Pro-Arg-Cys-Gly-Val-Pro-Asp-NH2 | - |
Echinoidea | |
EDTA | completely inhibited by 20 mM, inhibition is not reversible by Ca2+ | Echinoidea | |
jaspisin | - |
Echinoidea | |
Li+ | shifts the border of the envelysin expression domain towards the animal pole | Echinoidea | |
TIMP-1 | - |
Hemicentrotus pulcherrimus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | envelysin is probably packaged in secretory vesicles first localized between nucleus and the apical face | Echinoidea | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required for full activity | Echinoidea |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
47700 | - |
- |
Echinoidea |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fertilization envelope + H2O | Echinoidea | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Echinoidea | - |
- |
- |
Hemicentrotus pulcherrimus | - |
- |
- |
Paracentrotus lividus | - |
- |
- |
Strongylocentrotus purpuratus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by hydrophobic chromatography | Paracentrotus lividus |
by hydrophobic chromatography | Strongylocentrotus purpuratus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Echinoidea | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fertilization envelope + H2O | - |
Echinoidea | ? | - |
? | |
insulin | oxidized B chain of insulin cleaved at FVNQ-HLCGSHLVEA-LY-LVCGERGFF-YTPKA | Hemicentrotus pulcherrimus | ? | - |
? | |
additional information | short proteolyzed envelysin lacking the C-terminal part preferentially cleaves peptide bonds on the amino side of hydrophobic bulky residues (-Leu,-Ile,-Phe,-Tyr) | Hemicentrotus pulcherrimus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Echinoidea |
Synonyms | Comment | Organism |
---|---|---|
hatching enzyme | - |
Hemicentrotus pulcherrimus |
hatching enzyme | - |
Echinoidea |
hatching enzyme | - |
Paracentrotus lividus |
hatching enzyme | - |
Strongylocentrotus purpuratus |
HE | - |
Strongylocentrotus purpuratus |