3.4.23.17: Pro-opiomelanocortin converting enzyme

This is an abbreviated version!
For detailed information about Pro-opiomelanocortin converting enzyme, go to the full flat file.

Reaction

Cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side =

Synonyms

EC 3.4.99.38, More, PCE, POMC converting enzyme, Pro-opiomelanocortin-converting enzyme, Prohormone converting enzyme, Proopiomelanocortin proteinase, Proteinase, proopiomelanocortin, yapsin A

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.17 Pro-opiomelanocortin converting enzyme

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
1	CAS Registry Number
1	Cloned(Commentary)
21	Inhibitors
2	KM Value [mM]
9	Localization
4	Metals/Ions
7	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
14	Organism
9	pH Optimum
4	pH Range
1	pI Value
8	Posttranslational Modification
5	Purification (Commentary)
1	Reaction
1	Reaction Type
14	Reference
15	Source Tissue
3	Storage Stability
48	Substrates and Products (Substrate)
8	Subunits
11	Synonyms
3	Temperature Optimum [°C]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 3.4.23.17 - Pro-opiomelanocortin converting enzyme

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

beta-lipotropin + H2O

?

Bos taurus

-

-

668764

-

-

?

pro-enkephalin + H2O

?

Bos taurus

-

-

668764

-

-

?

pro-insulin + H2O

insulin chain A + insulin chain B

Bos taurus

-

cleavage of a Lys-Arg-/- and Arg-Arg-/- bonds

668764

-

-

?

pro-neuropeptide Y + H2O

?

Bos taurus

-

-

668764

-

-

?

Pro-opiomelanocortin + H2O

?

2 entries

pro-opiomelanocortin + H2O

opiomelanocortin + pro-sequence of opiomelanocortin

2 entries

pro-vasopressin + H2O

neurophysin + glycopeptide

Bos taurus

-

cleavage at a monobasic residue

668764

-

-

?

pro-vasopressin + H2O

vasopressin + pro-sequence of vasopressin

Bos taurus

-

cleavage of a Lys-Arg-/- bond

668764

-

-

?

additional information

?

-

Bos taurus

-

the enzyme is highly specific for mono- and dibasic residues of prohormones, overview

668764

-

-

?

Pro-opiomelanocortin + H2O

?

Bos taurus

-

may function as a pro-opiomelanocortin processing enzyme in the pituitary intermediate lobe

30546

-

-

?

Pro-opiomelanocortin + H2O

?

Mus musculus

-

physiological role of PC1 and PC2 as distinct proprotein convertases acting alone or together to produce a set of tissue-specific maturation products in the brain and in the peripheral tissues

30552

-

-

?

pro-opiomelanocortin + H2O

opiomelanocortin + pro-sequence of opiomelanocortin

Bos taurus

-

-

754446

-

-

?

pro-opiomelanocortin + H2O

opiomelanocortin + pro-sequence of opiomelanocortin

Bos taurus

-

hormone activation

668764

-

-

?