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Literature summary for 3.4.23.17 extracted from

  • Benjannet, S.; Rondeau, N.; Day, R.; Chretien, M.; Seidah, N.G.
    PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues (1991), Proc. Natl. Acad. Sci. USA, 88, 3564-3568.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
a recombinant vaccinia virus vector is used to coexpress mouse prohormone convertase PC1 and PC2 in the constitutively secreting cell line BSC-40 and in the endocrine tissue-derived cell lines PC12 and AtT-20 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Pro-opiomelanocortin + H2O Mus musculus physiological role of PC1 and PC2 as distinct proprotein convertases acting alone or together to produce a set of tissue-specific maturation products in the brain and in the peripheral tissues ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 a recombinant vaccinia virus vector is used to coexpress mouse prohormone convertase PC1 and PC2 in the constitutively secreting cell line BSC-40 and in the endocrine tissue-derived cell lines PC12 and AtT-20
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Pro-opiomelanocortin + H2O
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 Mus musculus Adrenocorticotropin + beta-lipotropin PC2: beta-endorphin + an N-terminally extended corticotropin containing the joining peptide + either alpha-melanotropin or desacetyl-alpha-melanotropin ?
Pro-opiomelanocortin + H2O
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 Mus musculus Adrenocorticotropin + beta-lipotropin PC2 cleaves at the five pairs of basic residues, PC1 cleaves two of them preferentially ?
Pro-opiomelanocortin + H2O
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 Mus musculus Adrenocorticotropin + beta-lipotropin PC1: corticotropin + beta-lipotropin ?
Pro-opiomelanocortin + H2O physiological role of PC1 and PC2 as distinct proprotein convertases acting alone or together to produce a set of tissue-specific maturation products in the brain and in the peripheral tissues Mus musculus ?
-
 ?