Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.22.B69: falcipain-2

This is an abbreviated version!
For detailed information about falcipain-2, go to the full flat file.

Word Map on EC 3.4.22.B69

Reaction

The enzyme plays a key role in the hydrolysis of hemoglobin by the parasite Plasmodium falciparum. Preferred cleavage sites display arginine in P1, leucine in P2, and phenylalanine in P1' =

Synonyms

falcipain 2, falcipain-2, FP-2, Fp2, haemoglobinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B69 falcipain-2

KI Value

KI Value on EC 3.4.22.B69 - falcipain-2

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
2-[3-(isobutylamino-methyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]-N-(4-oxo-pent-2-enyl)-acetamide
-
Ki above 0.1 mM, in 50 mM sodium acetate buffer, pH 5.5 containing 10 mM dithiothreitol, at 22°C
0.000065
benzyl [1-[(2-oxoethyl)carbamoyl]cyclohexyl]carbamate
pH and temperature not specified in the publication
0.0012
benzyl [1-[(cyanomethyl)carbamoyl]cyclohexyl]carbamate
pH and temperature not specified in the publication
0.0000065
chicken egg white cystatin
-
in 100 mM NaOAc, 10 mM dithiothreitol, at 22°C, pH not specified in the publication
-
0.00029
E-64
0.0002
N-((S)-1-(((S)-1-(((S)-1-(2-((4-fluorophenoxy)methyl)-4,5-dihydro-1H-imidazol-1-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)piperidine-1-carboxamide
pH 5.5, 23°C
0.0011
N-((S)-1-(((S)-1-(((S)-2-((S)-2-((4-fluorophenoxy)methyl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)morpholine-4-carboxamide
pH 5.5, 23°C
0.0021
N-(cyanomethyl)-1-([[(1S,2S)-2-phenylcyclopropyl]carbonyl]amino)cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0082
N-(cyanomethyl)-1-[(3-cyclopentylpropanoyl)amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0076
N-(cyanomethyl)-1-[(cyclopentylacetyl)amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0073
N-(cyanomethyl)-1-[[3-(2,3-dimethoxyphenyl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0052
N-(cyanomethyl)-1-[[3-(2-methoxyphenyl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0089
N-(cyanomethyl)-1-[[3-(4-methoxyphenyl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0172
N-(cyanomethyl)-1-[[3-(furan-2-yl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0094
N-(cyanomethyl)-1-[[3-(pyridin-3-yl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0088
N-(cyanomethyl)-1-[[3-(thiophen-2-yl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.002
RLLGAPV-(cis-4-aminocyclohexane carboxylic acid)-RQLVSGI
-
in 100 mM NaOAc, 10 mM dithiothreitol, at 22°C, pH not specified in the publication
0.0025
RLLGAPV-(cis-4-aminocyclohexane carboxylic acid)-RQLVSGI-betaAla-betaAla-PW
-
in 100 mM NaOAc, 10 mM dithiothreitol, at 22°C, pH not specified in the publication
0.0025
RLLGAPV-gamma-aminobutyric acid-RQLVSGI
-
in 100 mM NaOAc, 10 mM dithiothreitol, at 22°C, pH not specified in the publication
0.000338
SERPINB3
pH not specified in the publication, temperature not specified in the publication
-