3.4.22.B69: falcipain-2
This is an abbreviated version!
For detailed information about falcipain-2, go to the full flat file.
Word Map on EC 3.4.22.B69
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3.4.22.B69
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plasmodium
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falciparum
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antimalarial
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malaria
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hemoglobin
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falcipain-3
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antiplasmodial
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papain-family
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chloroquine-resistant
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hemoglobinases
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rhodesain
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prodomains
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plasmepsins
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hemozoin
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cruzain
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thiosemicarbazone
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chloroquine-sensitive
- 3.4.22.B69
- plasmodium
- falciparum
-
antimalarial
- malaria
- hemoglobin
-
falcipain-3
-
antiplasmodial
-
papain-family
-
chloroquine-resistant
- hemoglobinases
- rhodesain
- prodomains
-
plasmepsins
- hemozoin
- cruzain
-
thiosemicarbazone
-
chloroquine-sensitive
Reaction
The enzyme plays a key role in the hydrolysis of hemoglobin by the parasite Plasmodium falciparum. Preferred cleavage sites display arginine in P1, leucine in P2, and phenylalanine in P1' =
Synonyms
falcipain 2, falcipain-2, FP-2, Fp2, haemoglobinase
ECTree
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KI Value
KI Value on EC 3.4.22.B69 - falcipain-2
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0.1
2-[3-(isobutylamino-methyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]-N-(4-oxo-pent-2-enyl)-acetamide
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Ki above 0.1 mM, in 50 mM sodium acetate buffer, pH 5.5 containing 10 mM dithiothreitol, at 22°C
0.000065
benzyl [1-[(2-oxoethyl)carbamoyl]cyclohexyl]carbamate
pH and temperature not specified in the publication
0.0012
benzyl [1-[(cyanomethyl)carbamoyl]cyclohexyl]carbamate
pH and temperature not specified in the publication
0.0000065
chicken egg white cystatin
-
in 100 mM NaOAc, 10 mM dithiothreitol, at 22°C, pH not specified in the publication
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0.0002
N-((S)-1-(((S)-1-(((S)-1-(2-((4-fluorophenoxy)methyl)-4,5-dihydro-1H-imidazol-1-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)piperidine-1-carboxamide
pH 5.5, 23°C
0.0011
N-((S)-1-(((S)-1-(((S)-2-((S)-2-((4-fluorophenoxy)methyl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)morpholine-4-carboxamide
pH 5.5, 23°C
0.0021
N-(cyanomethyl)-1-([[(1S,2S)-2-phenylcyclopropyl]carbonyl]amino)cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0082
N-(cyanomethyl)-1-[(3-cyclopentylpropanoyl)amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0076
N-(cyanomethyl)-1-[(cyclopentylacetyl)amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0073
N-(cyanomethyl)-1-[[3-(2,3-dimethoxyphenyl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0052
N-(cyanomethyl)-1-[[3-(2-methoxyphenyl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0089
N-(cyanomethyl)-1-[[3-(4-methoxyphenyl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0172
N-(cyanomethyl)-1-[[3-(furan-2-yl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0094
N-(cyanomethyl)-1-[[3-(pyridin-3-yl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.0088
N-(cyanomethyl)-1-[[3-(thiophen-2-yl)propanoyl]amino]cyclohexanecarboxamide
pH and temperature not specified in the publication
0.002
RLLGAPV-(cis-4-aminocyclohexane carboxylic acid)-RQLVSGI
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in 100 mM NaOAc, 10 mM dithiothreitol, at 22°C, pH not specified in the publication
0.0025
RLLGAPV-(cis-4-aminocyclohexane carboxylic acid)-RQLVSGI-betaAla-betaAla-PW
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in 100 mM NaOAc, 10 mM dithiothreitol, at 22°C, pH not specified in the publication
0.0025
RLLGAPV-gamma-aminobutyric acid-RQLVSGI
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in 100 mM NaOAc, 10 mM dithiothreitol, at 22°C, pH not specified in the publication
0.000338
SERPINB3
pH not specified in the publication, temperature not specified in the publication
-
0.00029
E-64
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in 50 mM sodium acetate buffer, pH 5.5 containing 10 mM dithiothreitol, at 22°C