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3.4.22.B69: falcipain-2

This is an abbreviated version!
For detailed information about falcipain-2, go to the full flat file.

Word Map on EC 3.4.22.B69

Reaction

The enzyme plays a key role in the hydrolysis of hemoglobin by the parasite Plasmodium falciparum. Preferred cleavage sites display arginine in P1, leucine in P2, and phenylalanine in P1' =

Synonyms

falcipain 2, falcipain-2, FP-2, Fp2, haemoglobinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B69 falcipain-2

Reference

Reference on EC 3.4.22.B69 - falcipain-2

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pandey, K.C.; Barkan, D.T.; Sali, A.; Rosenthal, P.J.
Regulatory elements within the prodomain of falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum
PLoS ONE
4
e5694
2009
Plasmodium falciparum
Manually annotated by BRENDA team
Hansen, G.; Schwarzloh, B.; Rennenberg, A.; Heussler, V.T.; Hilgenfeld, R.
The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis
Acta Crystallogr. Sect. F
67
1406-1410
2011
Plasmodium falciparum
Manually annotated by BRENDA team
Huang, H.; Lu, W.; Li, X.; Cong, X.; Ma, H.; Liu, X.; Zhang, Y.; Che, P.; Ma, R.; Li, H.; Shen, X.; Jiang, H.; Huang, J.; Zhu, J.
Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent
Bioorg. Med. Chem. Lett.
22
958-962
2012
Plasmodium falciparum
Manually annotated by BRENDA team
Ettari, R.; Zappala, M.; Micale, N.; Grazioso, G.; Giofre, S.; Schirmeister, T.; Grasso, S.
Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors
Eur. J. Med. Chem.
46
2058-2065
2011
Plasmodium falciparum
Manually annotated by BRENDA team
Rizzi, L.; Sundararaman, S.; Cendic, K.; Vaiana, N.; Korde, R.; Sinha, D.; Mohmmed, A.; Malhotra, P.; Romeo, S.
Design and synthesis of protein-protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors
Eur. J. Med. Chem.
46
2083-2090
2011
Plasmodium falciparum
Manually annotated by BRENDA team
Micale, N.; Cinellu, M.A.; Maiore, L.; Sannella, A.R.; Severini, C.; Schirmeister, T.; Gabbiani, C.; Messori, L.
Selected gold compounds cause pronounced inhibition of Falcipain 2 and effectively block P. falciparum growth in vitro
J. Inorg. Biochem.
105
1576-1579
2011
Plasmodium falciparum
Manually annotated by BRENDA team
Ehmke, V.; Kilchmann, F.; Heindl, C.; Cui, K.; Huang, J.; Schirmeister, T.; Diederich, F.
Peptidomimetic nitriles as selective inhibitors for the malarial cysteine protease falcipain-2
MedChemComm
2
800-804
2011
Plasmodium falciparum (Q9N6S8)
-
Manually annotated by BRENDA team
Marques, A.F.; Gomes, P.S.; Oliveira, P.L.; Rosenthal, P.J.; Pascutti, P.G.; Lima, L.M.
Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme
Arch. Biochem. Biophys.
573
92-99
2015
Plasmodium falciparum
Manually annotated by BRENDA team
Singh, A.K.; Rajendran, V.; Pant, A.; Ghosh, P.C.; Singh, N.; Latha, N.; Garg, S.; Pandey, K.C.; Singh, B.K.; Rathi, B.
Design, synthesis and biological evaluation of functionalized phthalimides: A new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite
Bioorg. Med. Chem.
23
1817-1827
2015
Plasmodium falciparum
Manually annotated by BRENDA team
Sharma, R.K.; Younis, Y.; Mugumbate, G.; Njoroge, M.; Gut, J.; Rosenthal, P.J.; Chibale, K.
Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2
Eur. J. Med. Chem.
90
507-518
2015
Plasmodium falciparum, Plasmodium falciparum W2
Manually annotated by BRENDA team
Omotuyi, I.O.; Hamada, T.
Dynamical footprint of falcipain-2 catalytic triad in hemoglobin-beta-bound state
J. Biomol. Struct. Dyn.
33
1027-1036
2015
Plasmodium falciparum
Manually annotated by BRENDA team
Grazioso, G.; Legnani, L.; Toma, L.; Ettari, R.; Micale, N.; De Micheli, C.
Mechanism of falcipain-2 inhibition by alpha,beta-unsaturated benzo[1,4]diazepin-2-one methyl ester
J. Comput. Aided Mol. Des.
26
1035-1043
2012
Plasmodium falciparum
Manually annotated by BRENDA team
Bertoldo, J.B.; Chiaradia-Delatorre, L.D.; Mascarello, A.; Leal, P.C.; Cordeiro, M.N.; Nunes, R.J.; Sarduy, E.S.; Rosenthal, P.J.; Terenzi, H.
Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum
J. Enzyme Inhib. Med. Chem.
30
299-307
2015
Plasmodium falciparum
Manually annotated by BRENDA team
Cotrin, S.S.; Gouvea, I.E.; Melo, P.M.; Bagnaresi, P.; Assis, D.M.; Araujo, M.S.; Juliano, M.A.; Gazarini, M.L.; Rosenthal, P.J.; Juliano, L.; Carmona, A.K.
Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity
Mol. Biochem. Parasitol.
187
111-116
2013
Plasmodium falciparum
Manually annotated by BRENDA team
Alam, B.; Biswas, S.
Inhibition of Plasmodium falciparum cysteine protease falcipain-2 by a human cross-class inhibitor serpinB3 A mechanistic insight
Biochim. Biophys. Acta
1867
854-865
2019
Plasmodium falciparum (Q9N6S8), Plasmodium falciparum
Manually annotated by BRENDA team
Chakka, S.K.; Kalamuddin, M.; Sundararaman, S.; Wei, L.; Mundra, S.; Mahesh, R.; Malhotra, P.; Mohmmed, A.; Kotra, L.P.
Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents
Bioorg. Med. Chem.
23
2221-2240
2015
Plasmodium falciparum (Q9N6S8)
Manually annotated by BRENDA team
Nizi, E.; Sferrazza, A.; Fabbrini, D.; Nardi, V.; Andreini, M.; Graziani, R.; Gennari, N.; Bresciani, A.; Paonessa, G.; Harper, S.
Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins
Bioorg. Med. Chem. Lett.
28
1540-1544
2018
Plasmodium falciparum (Q9N6S8), Plasmodium falciparum
Manually annotated by BRENDA team
Himangini, Z.; Pathak, D.P.; Sharma, V.; Kumar, S.
Designing novel inhibitors against falcipain-2 of Plasmodium falciparum
Bioorg. Med. Chem. Lett.
28
1566-1569
2018
Plasmodium berghei, Plasmodium falciparum (Q9N6S8), Plasmodium falciparum
Manually annotated by BRENDA team
Akhter, M.; Saha, R.; Tanwar, O.; Mumtaz Alam, M.; Zaman, M.
Synthesis and antimalarial activity of quinoline-substituted furanone derivatives and their identification as selective falcipain-2 inhibitors
Med. Chem. Res.
24
879-890
2015
Plasmodium falciparum (Q9N6S8)
-
Manually annotated by BRENDA team
Ghogomu, J.; Nkungli, N.
DFT studies and topological analyses of electron density on acetophenone and propiophenone thiosemicarbazone derivatives as covalent inhibitors of falcipain-2, a major Plasmodium falciparum cysteine protease
Phys. Chem. Res.
5
795-817
2017
Plasmodium falciparum (Q9N6S8)
-
Manually annotated by BRENDA team
Hernandez Gonzalez, J.E.; Hernandez Alvarez, L.; Pascutti, P.G.; Valiente, P.A.
Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships
Proteins
85
1666-1683
2017
Plasmodium falciparum (Q9N6S8), Plasmodium falciparum
Manually annotated by BRENDA team