3.4.22.B65: cathepsin P
This is an abbreviated version!
For detailed information about cathepsin P, go to the full flat file.
Word Map on EC 3.4.22.B65
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3.4.22.B65
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cathepsins
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papain
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peptidyl
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rodent
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lysosomal
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proenzyme
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tubule
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phe
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perimembranous
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kupffer
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cytred
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giant
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papain-like
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peptidases
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propeptide
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pecs
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rcho-1
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hepatocytes
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na2so4
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immunolocalization
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trophoblast
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choriocarcinoma
-
preproprotein
- 3.4.22.B65
- cathepsins
- papain
-
peptidyl
- rodent
- lysosomal
- proenzyme
- tubule
- phe
-
perimembranous
-
kupffer
-
cytred
-
giant
-
papain-like
- peptidases
- propeptide
-
pecs
-
rcho-1
- hepatocytes
- na2so4
-
immunolocalization
-
trophoblast
- choriocarcinoma
- preproprotein
Reaction
Hydrolysis of proteins with restricted preference for substrates containing hydrophobic amino acids. Efficiently cleaves -Glu-Ile-Phe-/-Val-Phe-Lys-Gln-. Involved in the processing of endoplasmic proteins =
ECTree
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Substrates Products
Substrates Products on EC 3.4.22.B65 - cathepsin P
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REACTION DIAGRAM
7-(methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 + H2O
7-(methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly + Leu-Dap(Dnp)-Ala-Arg-NH2
calreticulin + H2O
?
endoplasmic reticulum protein substrate identified by incubation of recombinant enzyme with rat choriocarcinoma cell proteins
protein is processed from the C-terminus, with removal of the KDEL endoplasmic reticulum retention signal. Cathepsin L co-localizes with calreticulin in rat choriocarcinoma cell
-
?
Gp96 protein + H2O
?
endoplasmic reticulum protein substrate identified by incubation of recombinant enzyme with rat choriocarcinoma cell proteins
protein is sequentially processed by cathepsin P at 2 sites towards the C-terminus of the protein, with removal of the KDEL endoplasmic reticulum retention signal. Cathepsin L co-localizes with gp96 in rat choriocarcinoma cell
-
?
o-aminobenzoic acid-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-ALR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-EIFVFKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-EIF + VFKQ-N-(2,4-dinitrophenyl)ethylenediamine
ideal substrate constructed after analysis of substrate preferences. In contrast to most substrates, hydrolysis is not stimulated by addition of salts
-
-
?
o-aminobenzoic acid-ELRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-ELR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-FLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-FLR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-HLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-HLR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-ILRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-ILR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KARSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KAR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KFRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KFR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KIRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KIR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLASSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLA + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLFSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLF + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLISSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLI + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + o-aminobenzoic acid-KLIS + SKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
preferential hydrolysis at the Ser-Ser bond
-
?
o-aminobenzoic acid-KLKSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLK + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLLSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLL + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLMSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLM + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLQSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLQ + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLRESKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + ESKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLRfSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + fSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLRGSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + GSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLRHSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + HSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLRISKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + ISKQ-N-(2,4-dinitrophenyl)ethylenediamine + o-aminobenzoic acid-KLRIS + KQ-N-(2,4-dinitrophenyl)ethylenediamine
-
30% cleavage at Arg-Ile bond, 70% cleavage at Ser-Lys bond
-
?
o-aminobenzoic acid-KLRLSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + LSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLRNSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + NSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLRQSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + QSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLRRSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + RSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLRVSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLR + VSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLTSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLT + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KLYSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KLY + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KMRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KMR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KNLRSSKQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
?
-
-
-
?
o-aminobenzoic acid-KQRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KQR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KRRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KRR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KTRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KTR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KVRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KVR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-KYRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-KYR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-LLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-LLR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-NLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-NLR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-RLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-RLR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
o-aminobenzoic acid-VLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
o-aminobenzoic acid-VLR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
7-(methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly + Leu-Dap(Dnp)-Ala-Arg-NH2
-
-
-
?
7-(methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 + H2O
7-(methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly + Leu-Dap(Dnp)-Ala-Arg-NH2
-
-
-
-
?
7-(methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 + H2O
7-(methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly + Leu-Dap(Dnp)-Ala-Arg-NH2
-
-
-
-
?
?
-
no substrates: Z-Phe-Arg-NHMec, Z-Arg-Arg-NHMec, Arg-NHMec, Bz-Phe-Val-Arg-NHMec, succinyl-Ala-Ala-Phe-NHMec, Z-Val-Ala-Asp-NHMec, bradykinin, somatostatin, Fmoc-Tyr-Ala-OH, Z-Gly-Gly-OH, Z-Leu-Tyr-OH, Dnp-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2, Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 or Dnp-Pro-cyclohexyl-Ala-Gly-Cys(Me)-His-Ala-Lys(Nma)NH2
-
-
?
additional information
?
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-
no substrates: Z-Phe-Arg-NHMec, Z-Arg-Arg-NHMec, Arg-NHMec, Bz-Phe-Val-Arg-NHMec, succinyl-Ala-Ala-Phe-NHMec, Z-Val-Ala-Asp-NHMec, bradykinin, somatostatin, Fmoc-Tyr-Ala-OH, Z-Gly-Gly-OH, Z-Leu-Tyr-OH, Dnp-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2, Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 or Dnp-Pro-cyclohexyl-Ala-Gly-Cys(Me)-His-Ala-Lys(Nma)NH2
-
-
?
additional information
?
-
peptides with hydrophobic residues such as Phe, Met, and Leu in the P1 position are preferred substrates of cathepsin P. Substrates with negatively charged amino acids such as Glu, polar uncharged amino acids such as Asn, Gln, Ser, and Thr, and positively charged amino acids such as Arg, Lys, and His in this position are poorly hydrolyzed by cathepsin P due to either reduced kcat or increased Km, or both
-
-
?
additional information
?
-
-
peptides with hydrophobic residues such as Phe, Met, and Leu in the P1 position are preferred substrates of cathepsin P. Substrates with negatively charged amino acids such as Glu, polar uncharged amino acids such as Asn, Gln, Ser, and Thr, and positively charged amino acids such as Arg, Lys, and His in this position are poorly hydrolyzed by cathepsin P due to either reduced kcat or increased Km, or both
-
-
?