3.4.22.B36: calpain A

This is an abbreviated version!
For detailed information about calpain A, go to the full flat file.

Reaction

broad endopeptidase specificity =

Synonyms

calcium-activated neutral proteinase, CalpA, CALPA protein, calpain A, calpain-A, CANP, CAPLA

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B36 calpain A

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Results	in table
4	Activating Compound
1	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
5	General Information
1	Inhibitors
6	Localization
3	Metals/Ions
3	Natural Substrates/ Products (Substrates)
16	Organism
1	Protein Variants
1	Reaction
2	Reaction Type
12	Reference
21	Source Tissue
7	Substrates and Products (Substrate)
8	Synonyms

Substrates Products

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Substrates Products on EC 3.4.22.B36 - calpain A

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

cactus + H2O

?

2 entries

casein + H2O

hydrolyzed casein

Drosophila melanogaster

-

-

648418

-

-

?

N-succinyl-L-Leu-L-Tyr-7-amido-4-methylcoumarin + H2O

N-succinyl-L-Leu-L-Tyr + 7-amino-4-methylcoumarin

Drosophila melanogaster

-

-

709802

-

-

?

peptide + H2O

hydrolyzed peptide

2 entries

additional information

?

-

Drosophila melanogaster

-

the enzyme undergoes N-terminal autolysis in a Ca2+-dependent manner

648418

-

-

?

cactus + H2O

?

Drosophila melanogaster

Q11002

an IkappaB homo­logue, Cactus and calpain A physically interact, calpain A generates a C-terminal–truncated Cactus fragment devoid of Toll-responsive sequences, cleavage analysis in vivo, overview

732480

-

-

?

cactus + H2O

?

Drosophila melanogaster

Q11002

an IkappaB homo­logue, GFP-tagged substrate, calpain A generates a C-terminal–truncated Cactus fragment devoid of Toll-responsive sequences

732480

-

-

?

peptide + H2O

hydrolyzed peptide

Drosophila melanogaster

Q11002

calpain is involved in the dynamic changes in the embryonic cytoskeleton, especially actin-related structures, during early embryogenesis prior to cellularization

648415

-

-

?

peptide + H2O

hydrolyzed peptide

Drosophila melanogaster Canton-S

Q11002

calpain is involved in the dynamic changes in the embryonic cytoskeleton, especially actin-related structures, during early embryogenesis prior to cellularization

648415

-

-

?