3.4.22.B36: calpain A
This is an abbreviated version!
For detailed information about calpain A, go to the full flat file.
Word Map on EC 3.4.22.B36
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3.4.22.B36
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calcium-dependent
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ca2+-dependent
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calpeptin
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spectrin
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mcanp
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fodrin
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alln
- 3.4.22.B36
-
calcium-dependent
-
ca2+-dependent
- calpeptin
- spectrin
-
mcanp
- fodrin
- alln
Reaction
broad endopeptidase specificity =
Synonyms
calcium-activated neutral proteinase, CalpA, CALPA protein, calpain A, calpain-A, CANP, CAPLA
ECTree
3.4.22.B36 calpain AAdvanced search results
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results (General Information
General Information on EC 3.4.22.B36 - calpain A
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
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calpainA knockdowns increase Cactus levels, shifting the dorsal gradient and dorsal-ventral patterning. Decapentaplegic protein signals increase Cactus levels through calpain A inhibition, thereby interfering with Dorsal gene activation
physiological function
additional information
physiological function
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calpain A alters the size and position of Dorsal target gene expression domains, Cactus is regulated by calpain A, calpain A is regulated by Decapentaplegic signaling
physiological function
calpain A regulates regulate NFkappaB function by different mechanisms, it decreases IkappaB homologue cactus levels in vivo and regulates cactus function in the immune system. The enzyme interacts physically with cactus, recognizing a Cactus pool that is not bound to Dorsal, a fly NFkappaB/Rel homologue. The enzyme targets free cactus, which is incorporated into and modulates Toll-responsive complexes in the embryo and immune system. Effect of calpain A on the embryonic DV axis. Cactus regulates calpain A activity and localization
physiological function
a significant percentage of embryos from hypomorphic or knockdown calpain A mothers are lethal and do not complete embryogenesis. Lethality is increased as maternal calpain A function is reduced. Impaired Calpain A function results in loss of mitotic synchrony and ultimately halted embryonic development. Calpain A is required for the metaphase-to-anaphase transition, loss leads to presence of defective microtubules and chromosomal architecture at the mitotic spindle during metaphase and anaphase and perturbed levels of Cyclin B
additional information
cactus protein levels affect the cellular localization of the enzyme, overview. Wild-type syncytial blastoderm embryo show endogenous calpain A beneath the plasma membrane, while in loss-of-function cact mutants calpain A is diffuse in the cytoplasm. In a gain-of-function cact mutant, calpain A distribution is patchy during interphase and remains so during mitosis. Cactus regulates calpain A activity and localization
additional information
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cactus protein levels affect the cellular localization of the enzyme, overview. Wild-type syncytial blastoderm embryo show endogenous calpain A beneath the plasma membrane, while in loss-of-function cact mutants calpain A is diffuse in the cytoplasm. In a gain-of-function cact mutant, calpain A distribution is patchy during interphase and remains so during mitosis. Cactus regulates calpain A activity and localization
