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Literature summary for 3.4.22.B36 extracted from

  • Fontenele, M.; Carneiro, K.; Agrellos, R.; Oliveira, D.; Oliveira-Silva, A.; Vieira, V.; Negreiros, E.; Machado, E.; Araujo H.
    The Ca2+-dependent protease calpain A regulates cactus/I kappaB levels during Drosophila development in response to maternal Dpp signals (2009), Mech. Dev., 126, 737-751.
    View publication on PubMed
Search for more literature for 3.4.22.B36

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Drosophila melanogaster 5886
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-L-Leu-L-Tyr-7-amido-4-methylcoumarin + H2O
-
 Drosophila melanogaster N-succinyl-L-Leu-L-Tyr + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
CalpA
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction calpainA knockdowns increase Cactus levels, shifting the dorsal gradient and dorsal-ventral patterning. Decapentaplegic protein signals increase Cactus levels through calpain A inhibition, thereby interfering with Dorsal gene activation Drosophila melanogaster
physiological function calpain A alters the size and position of Dorsal target gene expression domains, Cactus is regulated by calpain A, calpain A is regulated by Decapentaplegic signaling Drosophila melanogaster