Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphatidic acid | activates | Drosophila melanogaster | |
phosphatidylinositol | activates | Drosophila melanogaster | |
phosphatidylinositol 4,5-bisphosphate | activates | Drosophila melanogaster | |
phosphatidylinositol 4-monophosphate | activates | Drosophila melanogaster |
Cloned (Comment) | Organism |
---|---|
expression of wild-type and truncated enzyme form, lacking the CALPA-specific unique insertion region | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the truncated enzyme form lacking the CALPA-specific unique insertion region. Although it lacks the 16-amino acid long putative membrane-anchoring segment, its activation by phospholipids is similar to that of the full-length CALPA protein | Drosophila melanogaster |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates, half-maximal activation of the full-length enzyme at 2.18 mM and for the truncated enzyme at 3.23 mM | Drosophila melanogaster | |
Mn2+ | slight activation | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | - |
Drosophila melanogaster | hydrolyzed casein | - |
? | |
additional information | the enzyme undergoes N-terminal autolysis in a Ca2+-dependent manner | Drosophila melanogaster | ? | - |
? |