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3.4.22.B28: calpain 8

This is an abbreviated version!
For detailed information about calpain 8, go to the full flat file.

Word Map on EC 3.4.22.B28

Reaction

broad endopeptidase specificity =

Synonyms

calpain, calpain 8/nCL-2, calpain-8a, CAPN 8, Capn8, CAPN9, More, nCL-2, nCL-2', nCL-2/calpain 8, stomach specific calpain nCL-2, stomach-specific calpain

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B28 calpain 8

Substrates Products

Substrates Products on EC 3.4.22.B28 - calpain 8

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
beta-subunit of the coat protein + H2O
?
show the reaction diagram
-
30°C, 5 mM Ca2+
-
-
?
calpain 8 + H2O
?
show the reaction diagram
-
one of the autolysis sites is between Ala5 and Ala6
-
-
?
peptide + H2O
hydrolyzed peptide
show the reaction diagram
additional information
?
-
calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, in which both molecules are essential for activity, and that is involved in gastric mucosal defense. Calpains 8 and 9 are regulated differently from each other and from conventional calpains and, thus, have potentially important, specific functions in the gastrointestinal tract. Calpains 8 and 9 are molecular chaperones for each other, overview
-
-
?