3.4.22.B28: calpain 8
This is an abbreviated version!
For detailed information about calpain 8, go to the full flat file.
Word Map on EC 3.4.22.B28
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3.4.22.B28
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calpastatin
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calcium-dependent
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caspase
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ca2+-dependent
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cytoskeletal
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calpeptin
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neurodegenerative
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ischemia
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neuroprotective
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proteasome
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calcium-activated
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alzheimer
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synaptic
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cathepsins
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hippocampal
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degeneration
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cortical
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proteinase
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platelet
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nmda
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neurotoxicity
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spectrin
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excitotoxicity
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reperfusion
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tau
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meat
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leupeptin
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tender
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traumatic
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ca2+-activated
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ionophore
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autolysis
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myofibrillar
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talin
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n-methyl-d-aspartate
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caspase-12
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neurofilament
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myofibril
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proteolyzed
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overactivation
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longissimus
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aif
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desmin
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lactacystin
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caspase-independent
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sarcomere
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limb-girdle
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bapta-am
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nmda-induced
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medicine
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troponin-t
- 3.4.22.B28
- calpastatin
-
calcium-dependent
-
caspase
-
ca2+-dependent
- cytoskeletal
- calpeptin
- neurodegenerative
- ischemia
-
neuroprotective
- proteasome
-
calcium-activated
- alzheimer
- synaptic
- cathepsins
- hippocampal
- degeneration
- cortical
- proteinase
- platelet
- nmda
-
neurotoxicity
- spectrin
-
excitotoxicity
-
reperfusion
- tau
-
meat
- leupeptin
-
tender
-
traumatic
-
ca2+-activated
-
ionophore
-
autolysis
- myofibrillar
- talin
- n-methyl-d-aspartate
- caspase-12
- neurofilament
- myofibril
-
proteolyzed
-
overactivation
- longissimus
- aif
- desmin
- lactacystin
-
caspase-independent
- sarcomere
-
limb-girdle
- bapta-am
-
nmda-induced
- medicine
-
troponin-t
Reaction
broad endopeptidase specificity =
Synonyms
calpain, calpain 8/nCL-2, calpain-8a, CAPN 8, Capn8, CAPN9, More, nCL-2, nCL-2', nCL-2/calpain 8, stomach specific calpain nCL-2, stomach-specific calpain
ECTree
3.4.22.B28 calpain 8Advanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.B28 - calpain 8
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
peptide + H2O
hydrolyzed peptide
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specific regulatory function of the enzyme in digestive tract
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?
additional information
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calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, in which both molecules are essential for activity, and that is involved in gastric mucosal defense. Calpains 8 and 9 are regulated differently from each other and from conventional calpains and, thus, have potentially important, specific functions in the gastrointestinal tract. Calpains 8 and 9 are molecular chaperones for each other, overview
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