3.4.22.B25: calpain 5
This is an abbreviated version!
For detailed information about calpain 5, go to the full flat file.
Word Map on EC 3.4.22.B25
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3.4.22.B25
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vitreoretinopathy
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neovascularization
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retinal
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adniv
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uveitis
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photoreceptors
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intraocular
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calcium-activated
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calmodulin-like
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electroretinography
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medicine
- 3.4.22.B25
-
vitreoretinopathy
- neovascularization
- retinal
-
adniv
- uveitis
-
photoreceptors
-
intraocular
-
calcium-activated
-
calmodulin-like
-
electroretinography
- medicine
Reaction
broad endopeptidase specificity =
Synonyms
calpain htra-3, calpain-5, CAPN5, htra-3, nCL-3
ECTree
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Application
Application on EC 3.4.22.B25 - calpain 5
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medicine
CAPN5 plays a role in polycystic ovary syndrome susceptibility in humans. The haplotypes H (GGCA) and I (GGTG) are overrepresented in patients when compared with controls. The presence of familial antecedents of obesity and essential hypertension in polycystic ovary syndrome women is associated with a non-random distribution of CAPN5 haplotypes. Association between CAPN5 gene and polycystic ovary syndrome patients with amenorrhoea and aggregation of diabetes mellitus
medicine
hepatitis C uses the membrane protein CD81 to invade human liver cells. Calpain-5 and the ubiquitin ligase Casitas B-lineage lymphoma proto-oncogene CBLB form a complex with CD81 and support hepatitis C virus entry. Calpain-5 and CBLB are required for a post-binding and pre-replication step in the hepatitis C virus life cycle. Knockout of calpain-5 and CBLB reduces susceptibility to all tested hepatitis C virus genotypes