3.4.22.B25: calpain 5
This is an abbreviated version!
For detailed information about calpain 5, go to the full flat file.
Word Map on EC 3.4.22.B25
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3.4.22.B25
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vitreoretinopathy
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neovascularization
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retinal
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adniv
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uveitis
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photoreceptors
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intraocular
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calcium-activated
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calmodulin-like
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electroretinography
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medicine
- 3.4.22.B25
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vitreoretinopathy
- neovascularization
- retinal
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adniv
- uveitis
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photoreceptors
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intraocular
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calcium-activated
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calmodulin-like
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electroretinography
- medicine
Reaction
broad endopeptidase specificity =
Synonyms
calpain htra-3, calpain-5, CAPN5, htra-3, nCL-3
ECTree
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Localization
Localization on EC 3.4.22.B25 - calpain 5
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calpain-5 is localized in the mitochondria of photoreceptor cells and is present in each mitochondrial subfraction. The molecular weight of mitochondrial calpain-5 is slightly smaller than the cytosolic one
additional information
the enzyme carries the nuclear localization signal RRRK (aa 2124)
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the enzyme carries dual nuclear localization signals
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unlike findings in classical calpains, which are characterized as being mainly cytosolic, CAPN5 is predominantly a noncytosolic calpain, present in the nucleus in the nucleic acidbinding protein fraction. The enzyme CAPN5 is associated with one or more nuclear bodies. Non-nuclear, particularly perinuclear. CAPN5 is found in punctate domains associated with promyelocytic leukemia protein within the nucleus
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additional information
unlike findings in classical calpains, which are characterized as being mainly cytosolic, CAPN5 is predominantly a noncytosolic calpain, present in the nucleus in the nucleic acidbinding protein fraction. The enzyme is associated with nuclear promyelocytic leukemia protein bodies
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additional information
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unlike findings in classical calpains, which are characterized as being mainly cytosolic, CAPN5 is predominantly a noncytosolic calpain, present in the nucleus in the nucleic acidbinding protein fraction. The enzyme is associated with nuclear promyelocytic leukemia protein bodies
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additional information
unlike findings in classical calpains, which are characterized as being mainly cytosolic, CAPN5 is predominantly a noncytosolic calpain, present in the nucleus in the nucleic acidbinding protein fraction. The enzyme is associated with nuclear promyelocytic leukemia protein bodies
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additional information
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unlike findings in classical calpains, which are characterized as being mainly cytosolic, CAPN5 is predominantly a noncytosolic calpain, present in the nucleus in the nucleic acidbinding protein fraction. The enzyme is associated with nuclear promyelocytic leukemia protein bodies
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