3.4.22.B25: calpain 5
This is an abbreviated version!
For detailed information about calpain 5, go to the full flat file.
Word Map on EC 3.4.22.B25
-
3.4.22.B25
-
vitreoretinopathy
-
neovascularization
-
retinal
-
adniv
-
uveitis
-
photoreceptors
-
intraocular
-
calcium-activated
-
calmodulin-like
-
electroretinography
-
medicine
- 3.4.22.B25
-
vitreoretinopathy
- neovascularization
- retinal
-
adniv
- uveitis
-
photoreceptors
-
intraocular
-
calcium-activated
-
calmodulin-like
-
electroretinography
- medicine
Reaction
broad endopeptidase specificity =
Synonyms
calpain htra-3, calpain-5, CAPN5, htra-3, nCL-3
ECTree
Advanced search results
General Information
General Information on EC 3.4.22.B25 - calpain 5
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
evolution
physiological function
additional information
calpain 5 is a non-classical member of the calpain family. It lacks the EF hand motif characteristic of classical calpains but retains catalytic and Ca2 binding domains, and it contains a unique C-terminal domain
evolution
calpain 5 is a non-classical member of the calpain family. It lacks the EF hand motif characteristic of classical calpains but retains catalytic and Ca2 binding domains, and it contains a unique C-terminal domain
evolution
calpain 5 is a non-classical member of the calpain family. It lacks the EF hand motif characteristic of classical calpains but retains catalytic and Ca2 binding domains, and it contains a unique C-terminal domain
evolution
-
calpain 5 is a non-classical member of the calpain family. It lacks the EF hand motif characteristic of classical calpains but retains catalytic and Ca2 binding domains, and it contains a unique C-terminal domain
-
evolution
-
calpain 5 is a non-classical member of the calpain family. It lacks the EF hand motif characteristic of classical calpains but retains catalytic and Ca2 binding domains, and it contains a unique C-terminal domain
-
hepatitis C uses the membrane protein CD81 to invade human liver cells. Calpain-5 and the ubiquitin ligase Casitas B-lineage lymphoma proto-oncogene CBLB form a complex with CD81 and support hepatitis C virus entry. Calpain-5 and CBLB are required for a post-binding and pre-replication step in the hepatitis C virus life cycle. Knockout of calpain-5 and CBLB reduces susceptibility to all tested hepatitis C virus genotypes
physiological function
-
in a zebrafish model of chronic rod photoreceptor degeneration and regeneration, expression of Capn5 is increased. Acute light damage to the zebrafish retina is accompanied by an increase in expression of Capn5 in the surviving cones and in a subset of Mueller glia
the enzyme is associated with nuclear promyelocytic leukemia protein bodies
additional information
the enzyme is associated with nuclear promyelocytic leukemia protein bodies
additional information
the enzyme is associated with nuclear promyelocytic leukemia protein bodies
additional information
-
the enzyme is associated with nuclear promyelocytic leukemia protein bodies
-
additional information
-
the enzyme is associated with nuclear promyelocytic leukemia protein bodies
-