Information on EC 3.4.22.B25 - calpain 5

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.22.B25
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
calpain 5
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
broad endopeptidase specificity
show the reaction diagram
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylic acid amide hydrolysis
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-
endopeptidase; peptides, endopeptidase
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CAS REGISTRY NUMBER
COMMENTARY hide
78990-62-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene Capn5
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
peptide + H2O
hydrolyzed peptide
show the reaction diagram
additional information
?
-
-
CAPN5 seems to influence traits related to increased risk for cardiovascular diseases. CAPN5 may be a candidate gene for metabolic syndrome
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
CAPN5 seems to influence traits related to increased risk for cardiovascular diseases. CAPN5 may be a candidate gene for metabolic syndrome
-
-
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
MDL-28170
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blocks calpain-5 processing
N-ethylmaleimide
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blocks calpain-5 processing
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.6
calculated from amino acid sequence
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
strong expression
Manually annotated by BRENDA team
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strong expression
Manually annotated by BRENDA team
weak expression
Manually annotated by BRENDA team
-
strong expression
Manually annotated by BRENDA team
strong expression
Manually annotated by BRENDA team
-
strong expression
Manually annotated by BRENDA team
-
strong expression
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
73000
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
1 * 76000, SDS-PAGE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in COS-7 cells
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gene Capn5, DNA and amino acid sequence determination and analysis
gene Capn5, DNA and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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CAPN5 plays a role in polycystic ovary syndrome susceptibility in humans. The haplotypes H (GGCA) and I (GGTG) are overrepresented in patients when compared with controls. The presence of familial antecedents of obesity and essential hypertension in polycystic ovary syndrome women is associated with a non-random distribution of CAPN5 haplotypes. Association between CAPN5 gene and polycystic ovary syndrome patients with amenorrhoea and aggregation of diabetes mellitus