3.4.22.26: cancer procoagulant
This is an abbreviated version!
For detailed information about cancer procoagulant, go to the full flat file.
Word Map on EC 3.4.22.26
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3.4.22.26
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coagulation
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proteinase
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thromboembolic
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clot
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thrombosis
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intravascular
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gordon
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amnion-chorion
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hypercoagulability
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thrombin-antithrombin
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thrombogenic
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three-stage
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prothrombotic
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warfarin
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benson
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anti-cp
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k-dependent
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haemostatic
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x-activating
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medicine
- 3.4.22.26
- coagulation
- proteinase
-
thromboembolic
- clot
- thrombosis
-
intravascular
-
gordon
-
amnion-chorion
- hypercoagulability
-
thrombin-antithrombin
-
thrombogenic
-
three-stage
-
prothrombotic
- warfarin
-
benson
-
anti-cp
-
k-dependent
-
haemostatic
-
x-activating
- medicine
Reaction
specific cleavage of Arg-/-Ile bond in Factor X to form Factor Xa =
Synonyms
cancer procoagulant, CP
ECTree
3.4.22.26 cancer procoagulantAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.26 - cancer procoagulant
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
factor X + H2O
?
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that triggers blood coagulation by directly activating factor X in the absence of factor VII
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-
?
factor X + H2O
?
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that triggers blood coagulation by directly activating factor X in the absence of factor VII
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?
factor X + H2O
factor Xa
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cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade
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?
factor X + H2O
factor Xa
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cleavage of Arg-Ile bond, activation of the coaglutation factor X
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?
factor X + H2O
factor Xa
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cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade
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?
inactive factor X + H2O
active factor Xa + ?
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activation of blood coagulation factor X
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-
?
inactive factor X + H2O
active factor Xa + ?
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activation of blood coagulation factor X, degradation of factor X during 24 h
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?
inactive factor X + H2O
active factor Xa + ?
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activation of blood coagulation factor X
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?
additional information
?
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enzyme seems to be regulated allosterically
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?
additional information
?
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the activity of cancer procoagulant in cases of uterine leiomyomas, overview
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?
additional information
?
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the enzyme is able to stimulate blood platelet adhesion to fibrinogen and collagen, which can also play a role in metastatic spread of cancer as well as primary tumor growth
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?
additional information
?
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the enzyme plays a role in pathogenesis of cancer-related thrombosis, the enzyme concentration in serum is positively correlated to fibrinogen concentration, but negatively correlated to free protein S plasma content, determination of prothrobotic parameters and correlation to enzyme activity, overview
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?
additional information
?
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high level of cancer procoagulant is a risk factor for multiple myeloma
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?
additional information
?
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cancer procoagulant is a cysteine protease acting as an activator of coagulation factor X, the protein activates factor X in the absence of tissue factor and factor VII
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?
additional information
?
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rat and human cancer procoagulant activity bind similarly to antiCP antibodies
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?
