3.4.22.25: glycyl endopeptidase

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For detailed information about glycyl endopeptidase, go to the full flat file.

Reaction

preferential cleavage: Gly-/-, in proteins and small molecule substrates =

Synonyms

Chymopapain, Chymopapain M, CpXCP7, glycine endopeptidase, Glycyl endopeptidase, More, Papaya peptidase B, Papaya proteinase 4, Papaya proteinase IV, PPIV, Proteinase, glycine-specific

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.25 glycyl endopeptidase

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Results	in table
1	Activating Compound
4	AA Sequence
2	Application
2	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
2	General Information
21	Inhibitors
2	Ki Value [mM]
3	KM Value [mM]
4	Localization
6	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
21	Organism
1	PDB ID
6	pH Optimum
1	pH Range
1	pH Stability
4	Posttranslational Modification
2	Protein Variants
9	Purification (Commentary)
2	Reaction
3	Reaction Type
21	Reference
13	Source Tissue
35	Substrates and Products (Substrate)
2	Subunits
21	Synonyms
1	Temperature Optimum [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

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General Information on EC 3.4.22.25 - glycyl endopeptidase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Carica papaya

P05994

all four major papain-like cysteine proteases (PLCPs) purified from papaya latex, including papain, chymopapain, glycyl endopeptidase and caricain, are grouped into the lineage-specific expansion branch in the subfamily III of papain-like cysteine proteases (PLCPs). Tandem duplications play the dominant role in affecting copy number of PLCPs in plants. Significant variations in size of the PLCP subfamilies among species may reflect genetic adaptation of plant species to different environments. The lineage-specific expansion of papaya PLCPs of subfamily III might have been promoted by the continuous reciprocal selective effects of herbivore attack and plant defense. Phylogenetic analysis, conserved domain identification, gene duplication analysis, and chromosomal distribution of PLCPs, overview

753097

metabolism

Carica papaya

P05994

papain-like cysteine proteases (PLCPs), a large group of cysteine proteases structurally related to papain, play important roles in plant development, senescence, and defense responses

753097