3.4.22.10: streptopain

This is an abbreviated version!
For detailed information about streptopain, go to the full flat file.

Reaction

preferential cleavage with hydrophobic residues at P2, P1 and P1' =

Synonyms

EC 3.4.4.18, IdeS, IgG-degrading enzyme of Streptococcus pyogenes, interleukin-1beta convertase, More, proteinase, streptococcal, pyrogenic exotoxin B, SCP, SpcCEP, Spe B, SPE B protease, SPE B/SCP, SpeB, SPP, Steptococcus proteinase, streptococcal cysteine protease, Streptococcal cysteine proteinase, streptococcal erythrogenic toxin B, streptococcal proteinase, streptococcal pyogenic exotoxin B, streptococcal pyrogenic exotoxin B, streptococcal pyrogenic exotoxin B/cysteine protease, Streptococcus peptidase A, Streptococcus protease, streptopain

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.10 streptopain

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Results	in table
6	Activating Compound
168	AA Sequence
1	CAS Registry Number
16	Cloned(Commentary)
5	Crystallization (Commentary)
2	Expression
12	General Information
5	General Stability
1	IC50 Value
60	Inhibitors
10	kcat/KM [mM/s]
1	Ki Value [mM]
34	KM Value [mM]
7	Localization
2	Metals/Ions
28	Molecular Weight [Da]
68	Natural Substrates/ Products (Substrates)
70	Organism
11	PDB ID
7	pH Optimum
1	pH Stability
15	Posttranslational Modification
37	Protein Variants
15	Purification (Commentary)
3	Reaction
1	Reaction Type
66	Reference
2	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
2	Storage Stability
165	Substrates and Products (Substrate)
13	Subunits
85	Synonyms
10	Temperature Optimum [°C]
4	Temperature Stability [°C]
32	Turnover Number [1/s]

Turnover Number

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Turnover Number on EC 3.4.22.10 - streptopain

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.35 - 2.14

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

10 entries

2.3

benzyloxycarbonyl-Glu-Phe

Streptococcus sp.

-

-

81451

29.7 - 142

benzyloxycarbonyl-Lys-p-nitrophenyl ester

3 entries

1.09

benzyloxycarbonyl-Lys-Phe

Streptococcus sp.

-

-

81451

0.042

benzyloxycarbonyl-Val-Arg-4-methylcoumarinyl-7-amide

Streptococcus pyogenes

-

-

81453

1.52

cinnamoyl-Gly-p-nitrophenyl ester

Streptococcus sp.

-

-

81459

0.21

N-benzoyl-Gly-p-nitrophenyl ester

Streptococcus sp.

-

-

81459

118

N-benzyloxycarbonyl-Ala-p-nitrophenyl ester

Streptococcus sp.

-

-

81459

9.4

N-benzyloxycarbonyl-Gly-p-nitrophenyl ester

Streptococcus sp.

-

-

81459

176 - 190

Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester

4 entries

5.05

Nalpha-benzyloxycarbonyl-Lys-Phe

Streptococcus sp.

-

-

81451

174

Nalpha-benzyloxycarbonyl-Lys-phenyl ester

Streptococcus sp.

-

at pH 7.25

81460

8.6

Nalpha-benzyloxycarbonyl-Nepsilon-t-butyloxycarbonyl-Lys-Phe

Streptococcus sp.

-

-

81451

1.15

p-nitrobenzyloxycarbonyl-Gly-p-nitrophenyl ester

Streptococcus sp.

-

-

81459

0.147

t-butyloxycarbonyl-Gly-p-nitrophenyl ester

Streptococcus sp.

-

-

81459

4.31

tert-butyloxycarbonyl-Ala-p-nitrophenyl ester

Streptococcus sp.

-

-

81459

additional information

additional information

2 entries

-

0.35

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

Streptococcus pyogenes

-

mutant G384D, pH 7.4, 25°C

734185

0.39

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

Streptococcus pyogenes

-

mutant G380A, pH 7.4, 25°C

734185

0.4

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

Streptococcus pyogenes

-

mutant G378A, pH 7.4, 25°C

734185

0.52

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

Streptococcus pyogenes

-

mutant G384A, pH 7.4, 25°C

734185

0.57

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

Streptococcus pyogenes

-

mutant G382A, pH 7.4, 25°C

734185

0.6

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

Streptococcus pyogenes

-

mutant G381A, pH 7.4, 25°C

734185

0.62

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

Streptococcus pyogenes

-

mutant T379V, pH 7.4, 25°C

734185

0.63

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

Streptococcus pyogenes

-

mutant T379A, pH 7.4, 25°C

734185

0.69

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

Streptococcus pyogenes

-

wild-type, pH 7.4, 25°C

734185

2.14

acetyl-Ala-Ile-Arg-7-amino-4-methylcoumarin

Streptococcus pyogenes

-

mutant G385A, pH 7.4, 25°C

734185

29.7

benzyloxycarbonyl-Lys-p-nitrophenyl ester

Streptococcus sp.

-

pH 4.27

81451

89.8

benzyloxycarbonyl-Lys-p-nitrophenyl ester

Streptococcus sp.

-

pH 4.49

81451

142

benzyloxycarbonyl-Lys-p-nitrophenyl ester

Streptococcus sp.

-

pH 6.35

81451

176

Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester

Streptococcus sp.

-

at pH 5.53

81460

178

Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester

Streptococcus sp.

-

at pH 6.73

81460

182

Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester

Streptococcus sp.

-

at pH 6.21

81460

190

Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester

Streptococcus sp.

-

at pH 6.99

81460

additional information

additional information

Streptococcus sp.

-

effect of pH-value on the turnover numer for benzyloxycarbonyl-Lys-p-nitrophenyl ester

81451

-

additional information

additional information

Streptococcus sp.

-

effect of pH-value on the turnover number for phenyl alpha-N-benzyloxycarbonyl-L-lysinate

81460

-