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Literature summary for 3.4.22.10 extracted from

  • Kortt, A.A.; Liu, T.Y.
    On the mechanism of action of streptococcal proteinase. 3. The effect of pH, organic solvents, and deuterium oxide on the proteinase-catalyzed hydrolysis of N-acylamino acid esters (1973), Biochemistry, 12, 338-345.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3-Dibromoacetone rapid and complete loss of activity Streptococcus sp.
acetonitrile mixed type Streptococcus sp.
dimethyl sulfoxide competitive Streptococcus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information effect of pH-value on the Km-value for phenyl alpha-N-benzyloxycarbonyl-L-lysinate Streptococcus sp.
0.588
-
Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester at pH 7.25 Streptococcus sp.
0.605
-
Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester at pH 6.73 Streptococcus sp.
0.637
-
Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester at pH 6.99 Streptococcus sp.
0.664
-
Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester at pH 6.21 Streptococcus sp.
0.667
-
Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester at pH 5.53 Streptococcus sp.

Organism

Organism UniProt Comment Textmining
Streptococcus sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester + H2O
-
Streptococcus sp. ?
-
?
Nalpha-benzyloxycarbonyl-Lys-phenyl ester + H2O
-
Streptococcus sp. Nalpha-benzyloxycarbonyl-Lys + phenol
-
?
p-nitrophenyl-benzyloxycarbonyl-L-Ala + H2O
-
Streptococcus sp. ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information effect of pH-value on the turnover number for phenyl alpha-N-benzyloxycarbonyl-L-lysinate Streptococcus sp.
174
-
Nalpha-benzyloxycarbonyl-Lys-phenyl ester at pH 7.25 Streptococcus sp.
176
-
Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester at pH 5.53 Streptococcus sp.
178
-
Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester at pH 6.73 Streptococcus sp.
182
-
Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester at pH 6.21 Streptococcus sp.
190
-
Nalpha-benzyloxycarbonyl-Lys-p-nitrophenyl ester at pH 6.99 Streptococcus sp.